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    BASP1 brain abundant membrane attached signal protein 1 [ Homo sapiens (human) ]

    Gene ID: 10409, updated on 10-Dec-2024

    Summary

    Official Symbol
    BASP1provided by HGNC
    Official Full Name
    brain abundant membrane attached signal protein 1provided by HGNC
    Primary source
    HGNC:HGNC:957
    See related
    Ensembl:ENSG00000176788 MIM:605940; AllianceGenome:HGNC:957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP23; NAP22; CAP-23; NAP-22
    Summary
    This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]
    Expression
    Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues See more
    Orthologs
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    Genomic context

    See BASP1 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (17216823..17276834)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (17156199..17216216)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (17216932..17276943)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BASP1 antisense RNA 1 Neighboring gene uncharacterized LOC105374664 Neighboring gene Sharpr-MPRA regulatory region 6771 Neighboring gene Sharpr-MPRA regulatory region 14227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15948 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17218860-17219640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17227689-17228189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22424 Neighboring gene RNA, U6 small nuclear 1003, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15951 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17275743-17276243 Neighboring gene BASP1-FTH1P10 intergenic CAGE-defined low expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17311529-17312170 Neighboring gene aurora kinase A interacting protein 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14736 Neighboring gene RN7SK pseudogene 133

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (31 hits/1269 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of brain membrane attached signal protein 1 (BASP1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • MGC8555

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    Process Evidence Code Pubs
    involved_in diaphragm development  
    involved_in gonad development  
    involved_in mesenchymal to epithelial transition  
    involved_in metanephric mesenchyme development  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in podocyte differentiation  
    involved_in positive regulation of heart growth  
    involved_in positive regulation of metanephric ureteric bud development  
    involved_in protein homooligomerization PubMed 
    involved_in substantia nigra development PubMed 
    involved_in supramolecular fiber organization PubMed 
    involved_in thorax and anterior abdomen determination  
    Component Evidence Code Pubs
    part_of COP9 signalosome PubMed 
    located_in PML body PubMed 
    located_in cell junction  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoskeleton PubMed 
    located_in extracellular exosome PubMed 
    located_in growth cone  
    located_in nuclear matrix PubMed 
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    brain acid soluble protein 1
    Names
    22 kDa neuronal tissue-enriched acidic protein
    brain acid-soluble protein 1
    neuronal axonal membrane protein NAP-22
    neuronal tissue-enriched acidic protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271606.2 → NP_001258535.1  brain acid soluble protein 1

      See identical proteins and their annotated locations for NP_001258535.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000518, BM973114, BU181147, DA489123, DW458407, HY258599
      Consensus CDS
      CCDS3888.1
      UniProtKB/Swiss-Prot
      B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
      Related
      ENSP00000482066.1, ENST00000616743.1
      Conserved Domains (1) summary
      pfam05466
      Location:12 → 227
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. NM_006317.5 → NP_006308.3  brain acid soluble protein 1

      See identical proteins and their annotated locations for NP_006308.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000518, BM973114, BU181147, CN355202, HY258599
      Consensus CDS
      CCDS3888.1
      UniProtKB/Swiss-Prot
      B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
      Related
      ENSP00000319281.3, ENST00000322611.4
      Conserved Domains (1) summary
      pfam05466
      Location:12 → 227
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      17216823..17276834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      17156199..17216216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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