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    DLGAP1-AS2 DLGAP1 antisense RNA 2 [ Homo sapiens (human) ]

    Gene ID: 84777, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DLGAP1-AS2provided by HGNC
    Official Full Name
    DLGAP1 antisense RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:28146
    See related
    AllianceGenome:HGNC:28146
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLPAP1-AS2
    Summary
    Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon (RPKM 1.6), endometrium (RPKM 1.4) and 24 other tissues See more
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    Genomic context

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    See DLGAP1-AS2 in Genome Data Viewer
    Location:
    18p11.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (3603737..3610089)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (3763322..3769665)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (3603735..3610087)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene DLG associated protein 1 Neighboring gene zinc finger protein 592 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13050 Neighboring gene Sharpr-MPRA regulatory region 8249 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3595284-3596254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3596255-3597226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3601961-3602755 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3603326-3604525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3610951-3611462 Neighboring gene DLGAP1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3623835-3625034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3625199-3625770 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:3652584-3653783 Neighboring gene Sharpr-MPRA regulatory region 6172 Neighboring gene DLGAP1 antisense RNA 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9258 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m(6)A/c-Myc-dependent aerobic glycolysis. Zhang Q, et al. Cell Cycle, 2022 Dec. PMID 35972892, Free PMC Article
    2. LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target. Soltani R, et al. Mol Biol Rep, 2022 Jul. PMID 34981339
    3. DLGAP1-AS2 promotes human colorectal cancer progression through trans-activation of Myc. Ren C, et al. Mamm Genome, 2022 Dec. PMID 36222892
    4. Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers. Zhao F, et al. Curr Med Chem, 2023. PMID 36121088
    5. The knockdown of lncRNA DLGAP1-AS2 suppresses osteosarcoma progression by inhibiting aerobic glycolysis via the miR-451a/HK2 axis. Zheng C, et al. Cancer Sci, 2023 Dec. PMID 37817462, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The knockdown of lncRNA DLGAP1-AS2 suppresses osteosarcoma progression by inhibiting aerobic glycolysis via the miR-451a/HK2 axis.
      Title: The knockdown of lncRNA DLGAP1-AS2 suppresses osteosarcoma progression by inhibiting aerobic glycolysis via the miR-451a/HK2 axis.
    2. Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers.
      Title: Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers.
    3. METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m[6]A/c-Myc-dependent aerobic glycolysis.
      Title: METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m(6)A/c-Myc-dependent aerobic glycolysis.
    4. Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.
      Title: Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.
    5. DLGAP1-AS2 promotes human colorectal cancer progression through trans-activation of Myc.
      Title: DLGAP1-AS2 promotes human colorectal cancer progression through trans-activation of Myc.
    6. LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target.
      Title: LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target.
    7. LncRNA DLGAP1-AS2 regulates miR-503/cyclin D1 to promote cell proliferation in non-small cell lung cancer.
      Title: LncRNA DLGAP1-AS2 regulates miR-503/cyclin D1 to promote cell proliferation in non-small cell lung cancer.
    8. The long noncoding RNA DLGAP1-AS2 facilitates cholangiocarcinoma progression via miR-505 and GALNT10.
      Title: The long noncoding RNA DLGAP1-AS2 facilitates cholangiocarcinoma progression via miR-505 and GALNT10.
    9. lncRNA DLGAP1-AS2 Knockdown Inhibits Hepatocellular Carcinoma Cell Migration and Invasion by Regulating miR-154-5p Methylation.
      Title: lncRNA DLGAP1-AS2 Knockdown Inhibits Hepatocellular Carcinoma Cell Migration and Invasion by Regulating miR-154-5p Methylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • DLGAP1 antisense RNA 2 (non-protein coding)

    Clone Names

    • FLJ33783, FLJ92483, MGC11082

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_119377.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP002478

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      3603737..3610089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      3763322..3769665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032691.1: Suppressed sequence

      Description
      NM_032691.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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