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    BBX BBX high mobility group box domain containing [ Homo sapiens (human) ]

    Gene ID: 56987, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BBXprovided by HGNC
    Official Full Name
    BBX high mobility group box domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:14422
    See related
    Ensembl:ENSG00000114439 AllianceGenome:HGNC:14422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBP2; ARTC1; MDS001; HSPC339
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 26.5), thyroid (RPKM 14.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BBX in Genome Data Viewer
    Location:
    3q13.12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (107522962..107811339)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (110242748..110531095)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (107241809..107530186)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CCDC54 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:107127150-107127650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:107127651-107128151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20202 Neighboring gene long intergenic non-protein coding RNA 1990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:107188782-107189520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:107189521-107190259 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:107195157-107195742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20204 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:107317361-107318183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:107319851-107320351 Neighboring gene MPRA-validated peak4758 silencer Neighboring gene long intergenic non-protein coding RNA 635 Neighboring gene long intergenic non-protein coding RNA 636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:107646067-107646688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells. Wang HY, et al. J Immunol, 2005 Mar 1. PMID 15728473
    2. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. Sánchez-Díaz A, et al. Curr Genet, 2001 Sep. PMID 11680820
    3. Genome-wide and candidate gene association study of cigarette smoking behaviors. Caporaso N, et al. PLoS One, 2009. PMID 19247474, Free PMC Article
    4. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Jirawatnotai S, et al. Nature, 2011 Jun 8. PMID 21654808, Free PMC Article
    5. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide and candidate gene association study of cigarette smoking behaviors.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HMG box transcription factor BBX
    Names
    Ag recognized by Treg cells 1
    BBX, HMG-box containing
    HMG box-containing protein 2
    bobby sox homolog
    x 001 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142568.3 → NP_001136040.1  HMG box transcription factor BBX isoform 1

      See identical proteins and their annotated locations for NP_001136040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC072044, AC117477, AI168295, AK291757, AW131333, DA218136
      Consensus CDS
      CCDS46881.1
      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Related
      ENSP00000319974.8, ENST00000325805.13
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    2. NM_001276286.2 → NP_001263215.1  HMG box transcription factor BBX isoform 3

      See identical proteins and their annotated locations for NP_001263215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117477, AI168295, AW131333, BC131718, DA218136
      Consensus CDS
      CCDS63712.1
      UniProtKB/Swiss-Prot
      Q8WY36
      Related
      ENSP00000403860.2, ENST00000416476.6
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 303
      DUF2028; Domain of unknown function (DUF2028)

    3. NM_020235.7 → NP_064620.2  HMG box transcription factor BBX isoform 2

      See identical proteins and their annotated locations for NP_064620.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC117477, AF454941, AI168295, AW131333
      Consensus CDS
      CCDS2950.1
      UniProtKB/TrEMBL
      C9JA69
      Related
      ENSP00000408358.2, ENST00000415149.6
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      107522962..107811339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453646.2 → XP_024309414.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    2. XM_011513001.3 → XP_011511303.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_011511303.1

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    3. XM_047448599.1 → XP_047304555.1  HMG box transcription factor BBX isoform X8

      UniProtKB/TrEMBL
      C9JA69
      Related
      ENSP00000385530.1, ENST00000406780.5

    4. XM_005247644.5 → XP_005247701.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_005247701.1

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    5. XM_024453648.2 → XP_024309416.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    6. XM_024453647.2 → XP_024309415.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    7. XM_005247642.5 → XP_005247699.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_005247699.1

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    8. XM_005247643.5 → XP_005247700.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_005247700.1

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    9. XM_024453653.2 → XP_024309421.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    10. XM_047448597.1 → XP_047304553.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    11. XM_024453651.2 → XP_024309419.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    12. XM_024453649.2 → XP_024309417.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    13. XM_011513000.3 → XP_011511302.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_011511302.1

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    14. XM_047448598.1 → XP_047304554.1  HMG box transcription factor BBX isoform X5

      UniProtKB/TrEMBL
      A8K6U2

    15. XM_047448600.1 → XP_047304556.1  HMG box transcription factor BBX isoform X10

      UniProtKB/TrEMBL
      C9JA69

    16. XM_024453663.2 → XP_024309431.1  HMG box transcription factor BBX isoform X12

      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 315
      DUF2028; Domain of unknown function (DUF2028)

    17. XM_024453645.2 → XP_024309413.1  HMG box transcription factor BBX isoform X2

      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    18. XM_024453664.2 → XP_024309432.1  HMG box transcription factor BBX isoform X13

      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 315
      DUF2028; Domain of unknown function (DUF2028)

    19. XM_024453656.2 → XP_024309424.1  HMG box transcription factor BBX isoform X4

      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    20. XM_024453658.2 → XP_024309426.1  HMG box transcription factor BBX isoform X7

      UniProtKB/TrEMBL
      C9JA69
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    21. XM_024453667.2 → XP_024309435.1  HMG box transcription factor BBX isoform X15

      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 315
      DUF2028; Domain of unknown function (DUF2028)

    22. XM_024453661.2 → XP_024309429.1  HMG box transcription factor BBX isoform X9

      UniProtKB/TrEMBL
      C9JA69
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    23. XM_024453644.2 → XP_024309412.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A8K6U2
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    24. XM_024453657.2 → XP_024309425.1  HMG box transcription factor BBX isoform X6

      UniProtKB/TrEMBL
      C9JA69
      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 335
      DUF2028; Domain of unknown function (DUF2028)

    25. XM_024453662.2 → XP_024309430.1  HMG box transcription factor BBX isoform X11

      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 315
      DUF2028; Domain of unknown function (DUF2028)

    26. XM_024453665.2 → XP_024309433.1  HMG box transcription factor BBX isoform X14

      Conserved Domains (2) summary
      cd01388
      Location:91 → 162
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:203 → 315
      DUF2028; Domain of unknown function (DUF2028)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      110242748..110531095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347283.1 → XP_054203258.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    2. XM_054347288.1 → XP_054203263.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    3. XM_054347295.1 → XP_054203270.1  HMG box transcription factor BBX isoform X8

      UniProtKB/TrEMBL
      C9JA69

    4. XM_054347282.1 → XP_054203257.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    5. XM_054347286.1 → XP_054203261.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    6. XM_054347287.1 → XP_054203262.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    7. XM_054347284.1 → XP_054203259.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    8. XM_054347285.1 → XP_054203260.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    9. XM_054347289.1 → XP_054203264.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    10. XM_054347280.1 → XP_054203255.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A8K6U2

    11. XM_054347281.1 → XP_054203256.1  HMG box transcription factor BBX isoform X2

      UniProtKB/TrEMBL
      A8K6U2

    12. XM_054347291.1 → XP_054203266.1  HMG box transcription factor BBX isoform X4

      UniProtKB/TrEMBL
      A8K6U2

    13. XM_054347292.1 → XP_054203267.1  HMG box transcription factor BBX isoform X5

      UniProtKB/TrEMBL
      A8K6U2

    14. XM_054347293.1 → XP_054203268.1  HMG box transcription factor BBX isoform X6

      UniProtKB/TrEMBL
      C9JA69

    15. XM_054347294.1 → XP_054203269.1  HMG box transcription factor BBX isoform X7

      UniProtKB/TrEMBL
      C9JA69

    16. XM_054347296.1 → XP_054203271.1  HMG box transcription factor BBX isoform X9

      UniProtKB/TrEMBL
      C9JA69

    17. XM_054347297.1 → XP_054203272.1  HMG box transcription factor BBX isoform X10

      UniProtKB/TrEMBL
      C9JA69

    18. XM_054347290.1 → XP_054203265.1  HMG box transcription factor BBX isoform X3

      UniProtKB/Swiss-Prot
      A2RRM7, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6
      UniProtKB/TrEMBL
      A8K6U2

    19. XM_054347299.1 → XP_054203274.1  HMG box transcription factor BBX isoform X12

    20. XM_054347300.1 → XP_054203275.1  HMG box transcription factor BBX isoform X13

    21. XM_054347298.1 → XP_054203273.1  HMG box transcription factor BBX isoform X16

    22. XM_054347301.1 → XP_054203276.1  HMG box transcription factor BBX isoform X17

    23. XM_054347302.1 → XP_054203277.1  HMG box transcription factor BBX isoform X18

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WY36.1 GenPept UniProtKB/Swiss-Prot:Q8WY36

    Gene LinkOut

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