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    Ptpn18 protein tyrosine phosphatase, non-receptor type 18 [ Mus musculus (house mouse) ]

    Gene ID: 19253, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ptpn18provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 18provided by MGI
    Primary source
    MGI:MGI:108410
    See related
    Ensembl:ENSMUSG00000026126 AllianceGenome:MGI:108410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLP1; HSCF; FLP-1; Ptpk1; PTP-K1; PTP-HSCF
    Summary
    Enables non-membrane spanning protein tyrosine phosphatase activity. Acts upstream of or within blastocyst formation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human PTPN18 (protein tyrosine phosphatase non-receptor type 18). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in colon adult (RPKM 76.4), duodenum adult (RPKM 74.3) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptpn18 in Genome Data Viewer
    Location:
    1 B; 1 13.25 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34498827..34514811)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34459729..34473784)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E787 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP4, U3 small nucleolar ribonucleoprotein Neighboring gene STARR-positive B cell enhancer mm9_chr1:34519657-34519958 Neighboring gene predicted gene, 32504 Neighboring gene predicted gene 28417 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene, 32566 Neighboring gene serine protease 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells. Cheng J, et al. Blood, 1996 Aug 15. PMID 8695832
    2. Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells. Dosil M, et al. Blood, 1996 Dec 15. PMID 8977243
    3. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. Spencer S, et al. J Cell Biol, 1997 Aug 25. PMID 9265651, Free PMC Article
    4. Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. Gensler M, et al. J Biol Chem, 2004 Mar 26. PMID 14660651
    5. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Wang B, et al. Mol Cell Biol, 2001 Feb. PMID 11158295, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BDP1 has a role in negative regulation of HER2 signaling
      Title: Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 18
    Names
    fetal liver phosphatase 1
    NP_001407402.1
    NP_001407403.1
    NP_035336.2
    XP_036018686.1
    XP_036018687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420473.1 → NP_001407402.1  tyrosine-protein phosphatase non-receptor type 18 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106841

    2. NM_001420474.1 → NP_001407403.1  tyrosine-protein phosphatase non-receptor type 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106841

    3. NM_011206.2 → NP_035336.2  tyrosine-protein phosphatase non-receptor type 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK144353, CD740968, CJ166432
      Consensus CDS
      CCDS14867.1
      UniProtKB/Swiss-Prot
      Q4JFH4, Q61152, Q62404, Q922E3
      Related
      ENSMUSP00000027302.8, ENSMUST00000027302.14
      Conserved Domains (2) summary
      cd00047
      Location:59 → 290
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:56 → 290
      Y_phosphatase; Protein-tyrosine phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34498827..34514811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162793.1 → XP_036018686.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

      Conserved Domains (2) summary
      PRK14951
      Location:331 → 428
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cl28904
      Location:27 → 292
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_036162794.1 → XP_036018687.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

      Conserved Domains (2) summary
      PRK14951
      Location:299 → 420
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cl28904
      Location:27 → 260
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61152.1 GenPept UniProtKB/Swiss-Prot:Q61152

    Gene LinkOut

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