Relb avian reticuloendotheliosis viral (v-rel) oncogene related B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Relbprovided by MGI
Official Full Name: avian reticuloendotheliosis viral (v-rel) oncogene related Bprovided by MGI
Primary source: MGI:MGI:103289
See related: Ensembl:ENSMUSG00000002983 AllianceGenome:MGI:103289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: shep
Summary: Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of DNA-templated transcription; and non-canonical NF-kappaB signal transduction. Acts upstream of or within T-helper 1 cell differentiation; antigen processing and presentation; and myeloid dendritic cell differentiation. Located in cytosol and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in spleen adult (RPKM 33.2), adrenal adult (RPKM 28.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.93 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19340142..19363352, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19606217..19629438, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization.
Title: TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization.
Alleviation of experimental autoimmune encephalomyelitis by transferring low RelB expression tolerogenic dendritic cells.
Title: Alleviation of experimental autoimmune encephalomyelitis by transferring low RelB expression tolerogenic dendritic cells.
RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent.
Title: RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent.
A T cell-intrinsic function for NF-kappaB RelB in experimental autoimmune encephalomyelitis.
Title: A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis.
The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo.
Title: The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo.
RelB regulates basal and proinflammatory induction of conjunctival CCL2.
Title: RelB regulates basal and proinflammatory induction of conjunctival CCL2.
Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice.
Title: Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice.
RelB regulates the homeostatic proliferation but not the function of Tregs.
Title: RelB regulates the homeostatic proliferation but not the function of Tregs.
RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines.
Title: RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines.
Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance.
Title: Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Spontaneous (1)
Targeted (6) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Relb (e-PCR), detects polymorphism
- UniSTS:144340

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEP Inferred from Expression Pattern more info	PubMed
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor RelB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290457.2 → NP_001277386.1 transcription factor RelB isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC149052

Consensus CDS

CCDS71896.1

UniProtKB/TrEMBL

Q3U0K7, Q8K220

Related

ENSMUSP00000050166.9, ENSMUST00000049912.15

Conserved Domains (4) summary

cd07886
Location:100 → 271

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16179
Location:279 → 375

RHD_dimer; Rel homology dimerization domain

pfam16180
Location:1 → 72

RelB_leu_zip; RelB leucine zipper

pfam16181
Location:378 → 555

RelB_transactiv; RelB transactivation domain
NM_001417183.1 → NP_001404112.1 transcription factor RelB isoform 3

Status: VALIDATED

Source sequence(s)

AC149052

UniProtKB/TrEMBL

Q3U0K7
NM_001417184.1 → NP_001404113.1 transcription factor RelB isoform 3

Status: VALIDATED

Source sequence(s)

AC149052

UniProtKB/TrEMBL

Q3U0K7
NM_001417185.1 → NP_001404114.1 transcription factor RelB isoform 4

Status: VALIDATED

Source sequence(s)

AC149052
NM_009046.3 → NP_033072.2 transcription factor RelB isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC149052

Consensus CDS

CCDS39799.1

UniProtKB/Swiss-Prot

Q04863, Q8VE46

UniProtKB/TrEMBL

Q3U0K7

Related

ENSMUSP00000092355.4, ENSMUST00000094762.10

Conserved Domains (4) summary

cd07886
Location:103 → 274

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16179
Location:282 → 378

RHD_dimer; Rel homology dimerization domain

pfam16180
Location:1 → 75

RelB_leu_zip; RelB leucine zipper

pfam16181
Location:381 → 558

RelB_transactiv; RelB transactivation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19340142..19363352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250461.4 → XP_011248763.1 transcription factor RelB isoform X1

UniProtKB/TrEMBL

Q3U0K7

Conserved Domains (3) summary

cd07886
Location:46 → 217

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16181
Location:324 → 501

RelB_transactiv; RelB transactivation domain

pfam16179
Location:225 → 320

RHD_dimer; Rel homology dimerization domain
XM_011250459.4 → XP_011248761.1 transcription factor RelB isoform X1

UniProtKB/TrEMBL

Q3U0K7

Conserved Domains (3) summary

cd07886
Location:46 → 217

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16181
Location:324 → 501

RelB_transactiv; RelB transactivation domain

pfam16179
Location:225 → 320

RHD_dimer; Rel homology dimerization domain
XM_006539675.2 → XP_006539738.1 transcription factor RelB isoform X1

UniProtKB/TrEMBL

Q3U0K7

Conserved Domains (3) summary

cd07886
Location:46 → 217

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16181
Location:324 → 501

RelB_transactiv; RelB transactivation domain

pfam16179
Location:225 → 320

RHD_dimer; Rel homology dimerization domain
XM_011250460.4 → XP_011248762.1 transcription factor RelB isoform X1

UniProtKB/TrEMBL

Q3U0K7

Conserved Domains (3) summary

cd07886
Location:46 → 217

RHD-n_RelB; N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein

pfam16181
Location:324 → 501

RelB_transactiv; RelB transactivation domain

pfam16179
Location:225 → 320

RHD_dimer; Rel homology dimerization domain
XM_036152807.1 → XP_036008700.1 transcription factor RelB isoform X2

Conserved Domains (3) summary

pfam16179
Location:42 → 138

RHD_dimer; Rel homology dimerization domain

pfam16181
Location:141 → 318

RelB_transactiv; RelB transactivation domain

cl08275
Location:1 → 34

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)