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    Sfxn1 sideroflexin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14057, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sfxn1provided by MGI
    Official Full Name
    sideroflexin 1provided by MGI
    Primary source
    MGI:MGI:2137677
    See related
    Ensembl:ENSMUSG00000021474 AllianceGenome:MGI:2137677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810002O05Rik; A930015P12Rik
    Summary
    Enables L-serine transmembrane transporter activity. Involved in serine import into mitochondrion. Acts upstream of or within erythrocyte differentiation and iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human SFXN1 (sideroflexin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 32.7), large intestine adult (RPKM 19.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sfxn1 in Genome Data Viewer
    Location:
    13 B1; 13 28.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54225675..54262365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54071656..54108346)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34557 Neighboring gene dopamine receptor D1 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 34640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hereditary anemias of the mouse: a review for geneticists. Russell ES. Adv Genet, 1979. PMID 390999
    2. Hemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice. Chui DH, et al. Blood, 1977 Jul. PMID 559515
    3. Activities of haem synthetic enzymes in blood cells of pre-natal flexed-tailed (f/f) anaemic mice. Cole RJ, et al. J Embryol Exp Morphol, 1975 Oct. PMID 1194836
    4. Flexed Tail in the Mouse, Mus Musculus. Hunt HR, et al. Genetics, 1933 Jul. PMID 17246696, Free PMC Article
    5. Haemopoietic progenitor cells in prenatal congenitally anaemic 'flexed-tailed' (f/f) mice. Cole RJ, et al. Br J Haematol, 1976 Jul. PMID 1276083

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Spontaneous (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-alanine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-serine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-serine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-serine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-alanine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-serine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-serine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of one-carbon metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of one-carbon metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in serine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serine import into mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serine import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serine import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-1
    Names
    flexed tail

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428618.1 → NP_001415547.1  sideroflexin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176
      UniProtKB/Swiss-Prot
      Q3UB44, Q99JR1, Q9CZG4

    2. NM_001428619.1 → NP_001415548.1  sideroflexin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176
      UniProtKB/Swiss-Prot
      Q3UB44, Q99JR1, Q9CZG4

    3. NM_001428620.1 → NP_001415549.1  sideroflexin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176
      UniProtKB/Swiss-Prot
      Q3UB44, Q99JR1, Q9CZG4

    4. NM_001428621.1 → NP_001415550.1  sideroflexin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    5. NM_001428622.1 → NP_001415551.1  sideroflexin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    6. NM_001428624.1 → NP_001415553.1  sideroflexin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    7. NM_001428625.1 → NP_001415554.1  sideroflexin-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    8. NM_001428626.1 → NP_001415555.1  sideroflexin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    9. NM_027324.6 → NP_081600.1  sideroflexin-1 isoform 1

      See identical proteins and their annotated locations for NP_081600.1

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176
      Consensus CDS
      CCDS26525.1
      UniProtKB/Swiss-Prot
      Q3UB44, Q99JR1, Q9CZG4
      Related
      ENSMUSP00000021930.9, ENSMUST00000021930.10
      Conserved Domains (1) summary
      pfam03820
      Location:16 → 322
      Mtc; Tricarboxylate carrier

    RNA

    1. NR_190428.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    2. NR_190429.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    3. NR_190430.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    4. NR_190431.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    5. NR_190432.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    6. NR_190433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    7. NR_190434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163343, CT030176

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54225675..54262365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516849.5 → XP_006516912.2  sideroflexin-1 isoform X1

      Conserved Domains (1) summary
      pfam03820
      Location:16 → 322
      Mtc; Tricarboxylate carrier

    2. XM_006516850.5 → XP_006516913.1  sideroflexin-1 isoform X1

      Conserved Domains (1) summary
      pfam03820
      Location:16 → 322
      Mtc; Tricarboxylate carrier

    RNA

    1. XR_003950425.1 RNA Sequence

    2. XR_004937937.1 RNA Sequence

    3. XR_003950424.2 RNA Sequence

    4. XR_004937936.1 RNA Sequence

    5. XR_004937939.1 RNA Sequence

    6. XR_004937938.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JR1.3 GenPept UniProtKB/Swiss-Prot:Q99JR1

    Gene LinkOut

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