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    Ankrd66 ankyrin repeat domain 66 [ Mus musculus (house mouse) ]

    Gene ID: 100043332, updated on 28-Dec-2024

    Summary

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    Official Symbol
    Ankrd66provided by MGI
    Official Full Name
    ankyrin repeat domain 66provided by MGI
    Primary source
    MGI:MGI:1925106
    See related
    Ensembl:ENSMUSG00000096140 AllianceGenome:MGI:1925106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4368; D730048J04Rik
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of telomere capping; and protein localization to chromosome, telomeric region. Predicted to be active in cytoplasm and nucleus. Orthologous to human ANKRD66 (ankyrin repeat domain 66). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd66 in Genome Data Viewer
    Location:
    17 B3; 17
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43845064..43862178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43534173..43551281, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha Neighboring gene STARR-seq mESC enhancer starr_42596 Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene STARR-seq mESC enhancer starr_42598 Neighboring gene tudor domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNAs expression profile of the developing mouse heart. Zhu JG, et al. J Cell Biochem, 2014 May. PMID 24375461
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001254953.3 → NP_001241882.1  ankyrin repeat domain-containing protein 66

      See identical proteins and their annotated locations for NP_001241882.1

      Status: VALIDATED

      Source sequence(s)
      CT010585
      Consensus CDS
      CCDS57095.1
      UniProtKB/TrEMBL
      J3QNN4
      Related
      ENSMUSP00000136879.2, ENSMUST00000178772.3
      Conserved Domains (3) summary
      COG0666
      Location:24 → 187
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:10 → 39
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 96
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001404112.1 → NP_001391041.1  ankyrin repeat domain-containing protein 66

      Status: VALIDATED

      Source sequence(s)
      CT010585
      UniProtKB/TrEMBL
      J3QNN4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43845064..43862178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523378.2 → XP_006523441.1  ankyrin repeat domain-containing protein 66 isoform X1

      Conserved Domains (3) summary
      COG0666
      Location:24 → 187
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:10 → 39
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 96
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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