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    Cdkl3 cyclin dependent kinase like 3 [ Mus musculus (house mouse) ]

    Gene ID: 213084, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cdkl3provided by MGI
    Official Full Name
    cyclin dependent kinase like 3provided by MGI
    Primary source
    MGI:MGI:2388268
    See related
    Ensembl:ENSMUSG00000020389 AllianceGenome:MGI:2388268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230379H01Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human CDKL3 (cyclin dependent kinase like 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in testis adult (RPKM 12.9), CNS E18 (RPKM 1.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdkl3 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.85 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51891694..51980605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52000842..52089778)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene predicted gene, 26061 Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene STARR-seq mESC enhancer starr_29438 Neighboring gene STARR-seq mESC enhancer starr_29439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51879429-51879612 Neighboring gene STARR-positive B cell enhancer ABC_E8875 Neighboring gene STARR-positive B cell enhancer ABC_E10674 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain. Liu Z, et al. Neurol Sci, 2015 Feb. PMID 25270654
    2. Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis. Liu Z, et al. Neurobiol Dis, 2010 Sep. PMID 20347982
    3. Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation. Dubos A, et al. Am J Med Genet A, 2008 May 15. PMID 18412109
    4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
    5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
      Title: Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain.
    2. CDKL3 is involved in neuronal morphogenesis during development.
      Title: Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28957

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 3
    NP_001160125.1
    NP_001160126.1
    NP_001160127.1
    NP_001160128.1
    NP_001160129.1
    NP_001350405.1
    NP_722480.3
    XP_006532830.1
    XP_006532831.1
    XP_006532832.1
    XP_006532833.1
    XP_006532836.1
    XP_011247165.1
    XP_011247170.1
    XP_011247172.1
    XP_011247173.1
    XP_011247174.1
    XP_011247176.1
    XP_011247180.1
    XP_011247183.1
    XP_030101618.1
    XP_030101620.1
    XP_030101622.1
    XP_030101623.1
    XP_030101624.1
    XP_036012392.1
    XP_036012393.1
    XP_036012394.1
    XP_036012395.1
    XP_036012396.1
    XP_036012397.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166653.1 → NP_001160125.1  cyclin-dependent kinase-like 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK045356, AK046394, AK050990, BB759970
      Consensus CDS
      CCDS48789.1
      UniProtKB/TrEMBL
      B1AU43, F2Z3Z6
      Related
      ENSMUSP00000104708.3, ENSMUST00000109080.9
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001166654.1 → NP_001160126.1  cyclin-dependent kinase-like 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK046394, AL669920
      Consensus CDS
      CCDS48790.1
      UniProtKB/TrEMBL
      F2Z3Z6
      Related
      ENSMUSP00000112477.2, ENSMUST00000121591.8
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001166655.1 → NP_001160127.1  cyclin-dependent kinase-like 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK046394, AK050990
      Consensus CDS
      CCDS48791.1
      UniProtKB/Swiss-Prot
      Q8BLF2
      Related
      ENSMUSP00000104706.2, ENSMUST00000109078.8
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001166656.1 → NP_001160128.1  cyclin-dependent kinase-like 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK046394, AK050990, AK078804
      Consensus CDS
      CCDS48788.1
      UniProtKB/TrEMBL
      F2Z3Z6
      Related
      ENSMUSP00000065128.7, ENSMUST00000063321.13
      Conserved Domains (2) summary
      smart00220
      Location:4 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001166657.1 → NP_001160129.1  cyclin-dependent kinase-like 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AK046394, AK050990
      Consensus CDS
      CCDS48792.1
      UniProtKB/Swiss-Prot
      Q8BLF2
      Related
      ENSMUSP00000104704.2, ENSMUST00000109076.2
      Conserved Domains (2) summary
      smart00220
      Location:4 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001363476.1 → NP_001350405.1  cyclin-dependent kinase-like 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669920
      Consensus CDS
      CCDS48791.1
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    7. NM_153785.4 → NP_722480.3  cyclin-dependent kinase-like 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK045356, AK046394, AL669920
      Consensus CDS
      CCDS24665.1
      UniProtKB/Swiss-Prot
      A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
      UniProtKB/TrEMBL
      F2Z3Z6
      Related
      ENSMUSP00000064315.5, ENSMUST00000063303.11
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_156698.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL669920, AL935177

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51891694..51980605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532773.4 → XP_006532836.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011248868.3 → XP_011247170.1  cyclin-dependent kinase-like 3 isoform X3

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011248863.3 → XP_011247165.1  cyclin-dependent kinase-like 3 isoform X2

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011248878.1 → XP_011247180.1  cyclin-dependent kinase-like 3 isoform X8

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030245762.1 → XP_030101622.1  cyclin-dependent kinase-like 3 isoform X9

      UniProtKB/TrEMBL
      F2Z3Z6
      Related
      ENSMUSP00000123279.2, ENSMUST00000143228.8
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    6. XM_011248874.2 → XP_011247176.1  cyclin-dependent kinase-like 3 isoform X6

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030245758.1 → XP_030101618.1  cyclin-dependent kinase-like 3 isoform X7

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    8. XM_006532768.2 → XP_006532831.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006532767.4 → XP_006532830.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    10. XM_006532770.2 → XP_006532833.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    11. XM_036156499.1 → XP_036012392.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    12. XM_006532769.4 → XP_006532832.1  cyclin-dependent kinase-like 3 isoform X1

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    13. XM_036156500.1 → XP_036012393.1  cyclin-dependent kinase-like 3 isoform X3

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    14. XM_011248870.4 → XP_011247172.1  cyclin-dependent kinase-like 3 isoform X4

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    15. XM_036156501.1 → XP_036012394.1  cyclin-dependent kinase-like 3 isoform X8

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    16. XM_030245760.1 → XP_030101620.1  cyclin-dependent kinase-like 3 isoform X8

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    17. XM_011248881.2 → XP_011247183.1  cyclin-dependent kinase-like 3 isoform X9

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    18. XM_011248871.3 → XP_011247173.1  cyclin-dependent kinase-like 3 isoform X4

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    19. XM_011248872.3 → XP_011247174.1  cyclin-dependent kinase-like 3 isoform X5

      UniProtKB/TrEMBL
      B1AU43, F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    20. XM_030245764.2 → XP_030101624.1  cyclin-dependent kinase-like 3 isoform X8

      UniProtKB/TrEMBL
      F2Z3Z6
      Related
      ENSMUSP00000104709.3, ENSMUST00000109081.9
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    21. XM_036156504.1 → XP_036012397.1  cyclin-dependent kinase-like 3 isoform X8

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    22. XM_036156502.1 → XP_036012395.1  cyclin-dependent kinase-like 3 isoform X6

      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    23. XM_036156503.1 → XP_036012396.1  cyclin-dependent kinase-like 3 isoform X10

      UniProtKB/Swiss-Prot
      A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    24. XM_030245763.2 → XP_030101623.1  cyclin-dependent kinase-like 3 isoform X10

      UniProtKB/Swiss-Prot
      A2ACR7, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLF2, Q8BLN9, Q8BVE0, Q8K134
      UniProtKB/TrEMBL
      F2Z3Z6
      Conserved Domains (1) summary
      cl21453
      Location:2 → 286
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004936900.1 RNA Sequence

    2. XR_003949370.1 RNA Sequence

    3. XR_004936901.1 RNA Sequence

    4. XR_004936902.1 RNA Sequence

    5. XR_004936906.1 RNA Sequence

    6. XR_004936905.1 RNA Sequence

    7. XR_004936907.1 RNA Sequence

    8. XR_004936908.1 RNA Sequence

    9. XR_879548.1 RNA Sequence

    10. XR_879549.1 RNA Sequence

    11. XR_003949373.1 RNA Sequence

    12. XR_004936904.1 RNA Sequence

    13. XR_879545.1 RNA Sequence

    14. XR_879546.1 RNA Sequence

    15. XR_879553.1 RNA Sequence

    16. XR_879554.2 RNA Sequence

    17. XR_004936909.1 RNA Sequence

    18. XR_003949374.2 RNA Sequence

    19. XR_003949379.2 RNA Sequence

    20. XR_004936903.1 RNA Sequence

    21. XR_003949375.2 RNA Sequence

    22. XR_003949378.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLF2.2 GenPept UniProtKB/Swiss-Prot:Q8BLF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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