mTor mechanistic Target of rapamycin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mTorprovided by FlyBase
Official Full Name: mechanistic Target of rapamycinprovided by FlyBase
Primary source: FLYBASE:FBgn0021796
Locus tag: Dmel_CG5092
See related: AllianceGenome:FB:FBgn0021796
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5092; CG5092; CT16317; CT24745; CT24817; Dmel\CG5092; DmTOR; dtor; dTor; dTOR; dTORC1; FRAP/TOR; l(2)k17004; mtor; mTOR; Mtor; MTOR; tor; Tor; TOR; Tor-C1; TOR-C1; Torc1; TORC1
Summary: Enables chromatin DNA binding activity and protein kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of catabolic process; and regulation of synapse organization. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 34A4-34A4; 2-47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13004480..13013197)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13004480..13013197)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-alpha/egr and ImpL2 signaling in Drosophila larvae.
Title: Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae.
Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
Title: Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
Title: Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
Title: Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.
Title: Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.
Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.
Title: Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.
FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
Title: Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation.
Title: Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation.
TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila.
Title: TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISM Inferred from Sequence Model more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in germarium-derived cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of TORC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: mechanistic target of rapamycin

Names: CG5092-PA; CG5092-PB; Target-of-rapamycin; mTOR; mTor-PA; mTor-PB; target of rapamycin; target of rapamycin complex 1; target of rapamycin kinase

NP_001260427.1

EC 2.7.11.1

NP_524891.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13004480..13013197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273498.1 → NP_001260427.1 mechanistic target of rapamycin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260427.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZYB7, H1ZYC1, M9PFS0

Conserved Domains (6) summary

COG5032
Location:308 → 2471

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd05169
Location:2075 → 2353

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2440 → 2471

FATC; FATC domain

pfam08771
Location:1937 → 2034

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:831 → 999

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:632 → 658

HEAT; HEAT repeat [structural motif]
NM_080152.3 → NP_524891.1 mechanistic target of rapamycin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524891.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VK45

UniProtKB/TrEMBL

H1ZYB5, H1ZYB7, H1ZYC1

Related

FBpp0080003

Conserved Domains (6) summary

COG5032
Location:347 → 2470

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd05169
Location:2074 → 2352

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2439 → 2470

FATC; FATC domain

pfam08771
Location:1936 → 2033

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:830 → 998

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:631 → 657

HEAT; HEAT repeat [structural motif]