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    Ir67a Ionotropic receptor 67a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir67aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 67aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036010
    Locus tag
    Dmel_CG12525
    See related
    AllianceGenome:FB:FBgn0036010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    67a; CG12525; DmelIR67a; Dmel\CG12525; IR67a
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the ventral organ; mesothoracic leg taste bristle chemosensory neurons; metathoracic leg taste bristle chemosensory neurons; and prothoracic leg taste bristle chemosensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir67a in Genome Data Viewer
    Location:
    67B13-67B13; 3-29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9542245..9543999, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9535345..9537099, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46246 Neighboring gene Transmembrane channel-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Candidate ionotropic taste receptors in the Drosophila larva. Stewart S, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25825777, Free PMC Article
    2. The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors. Koh TW, et al. Neuron, 2014 Aug 20. PMID 25123314, Free PMC Article
    3. A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster. Sang J, et al. Elife, 2024 Apr 4. PMID 38573740, Free PMC Article
    4. Avoiding cantharidin through ionotropic receptors. Pradhan RN, et al. J Hazard Mater, 2024 Mar 15. PMID 38278077
    5. A Molecular and Cellular Context-Dependent Role for Ir76b in Detection of Amino Acid Taste. Ganguly A, et al. Cell Rep, 2017 Jan 17. PMID 28099851, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 67a
    Names
    CG12525-PB
    Ir67a-PB
    NP_648329.3
    • point mutation, may be evolving pseudogene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9542245..9543999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140072.3 → NP_648329.3  ionotropic receptor 67a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648329.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT09
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT09 Q9VT09

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