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    Vha68-2 Vacuolar H[+] ATPase 68 kDa subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha68-2provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 68 kDa subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0263598
    Locus tag
    Dmel_CG3762
    See related
    AllianceGenome:FB:FBgn0263598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A subunit; ATP6V1A; CG3762; Dmel\CG3762; l(2)01510; l(2)s4214; MENE-R6; RE30552p; VATA; Vha6-2; vha67-2; Vha68; vha68-2; Vha68.2
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including endosomal lumen acidification; imaginal disc growth; and lumen formation, open tracheal system. Located in plasma membrane. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; epithelium; gut section; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha68-2 in Genome Data Viewer
    Location:
    34A3-34A3; 2-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12974322..12978607)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12974322..12978607)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44183 Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 68kD subunit 3 Neighboring gene Yip1 domain-containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vacuolar ATPase is required for ERK-dependent wound healing in the Drosophila embryo. Fraire-Zamora JJ, et al. Wound Repair Regen, 2018 Jan. PMID 29418044
    2. Functional domains are specified to single-cell resolution in a Drosophila epithelium. Sözen MA, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144216, Free PMC Article
    3. Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs. Chua SCJH, et al. Pharmaceuticals (Basel), 2019 Sep 30. PMID 31575020, Free PMC Article
    4. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Nikolova LS, et al. Development, 2015 Nov 15. PMID 26428009, Free PMC Article
    5. Proteomic changes in response to crystal formation in Drosophila Malpighian tubules. Chung VY, et al. Fly (Austin), 2016 Apr 2. PMID 27064297, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 68 kDa subunit 2
    Names
    CG3762-PA
    CG3762-PB
    CG3762-PC
    CG3762-PD
    CG3762-PE
    CG3762-PF
    V-ATPase 69 kDa subunit 2
    V-ATPase V1 subunit A1
    Vha68-2-PA
    Vha68-2-PB
    Vha68-2-PC
    Vha68-2-PD
    Vha68-2-PE
    Vha68-2-PF
    vacuolar ATPase
    vacuolar H[+] ATPase subunit 68-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12974322..12978607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273496.1 → NP_001260425.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    2. NM_143747.3 → NP_652004.2  vacuolar H[+] ATPase 68 kDa subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652004.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Related
      FBpp0079999
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    3. NM_165021.2 → NP_723775.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Related
      FBpp0080000
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    4. NM_165022.2 → NP_723776.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Related
      FBpp0080001
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    5. NM_001259086.2 → NP_001246015.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    6. NM_001273495.1 → NP_001260424.1  vacuolar H[+] ATPase 68 kDa subunit 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27331, Q8SXT2, Q9VK48
      UniProtKB/TrEMBL
      A4V0N4, V9GZU6
      Conserved Domains (1) summary
      TIGR01042
      Location:16 → 606
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V0N4 A4V0N4
    Q27331.2 Q27331

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