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    fig fos intronic gene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43511, updated on 27-Dec-2024

    Summary

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    Official Symbol
    figprovided by FlyBase
    Official Full Name
    fos intronic geneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039694
    Locus tag
    Dmel_CG7615
    See related
    AllianceGenome:FB:FBgn0039694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7615; Dmel\CG7615; PPTC7
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of ubiquinone biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fig in Genome Data Viewer
    Location:
    99C1-99C1; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29779273..29780452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25604995..25606174, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44953 Neighboring gene kayak Neighboring gene long non-coding RNA:CR46110 Neighboring gene shroud Neighboring gene R and B Neighboring gene Death related ICE-like caspase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene. Hudson SG, et al. Gene, 2008 Aug 15. PMID 18571877
    2. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Hudson SG, et al. Genetics, 2007 Nov. PMID 18039871, Free PMC Article
    3. The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q(10) biosynthesis. González-Mariscal I, et al. Biochim Biophys Acta Bioenerg, 2018 Nov. PMID 30267671
    4. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    5. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fos intronic gene
    Names
    CG7615-PA
    fig-PA
    fos intron gene
    fos-intronic gene
    NP_651724.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29779273..29780452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143467.4 → NP_651724.1  fos intronic gene [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MPH7, Q8SWZ0, Q9VAH4
      Related
      FBpp0084904
      Conserved Domains (1) summary
      cl00120
      Location:68 → 306
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAH4.1 Q9VAH4

    Gene LinkOut

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