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    Acp36DE Accessory gland protein 36DE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35096, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acp36DEprovided by FlyBase
    Official Full Name
    Accessory gland protein 36DEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011559
    Locus tag
    Dmel_CG7157
    See related
    AllianceGenome:FB:FBgn0011559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A36DE; Acp; Acp36D; Acp36De; AcpDE36; anon-WO0140519.55; CG7157; CT22109; Dmel\CG7157
    Summary
    Involved in sexual reproduction and sperm storage. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; female reproductive system; male accessory gland; and sperm storage organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acp36DE in Genome Data Viewer
    Location:
    36F3-36F3; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18356047..18359028, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18356047..18359026, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45721 Neighboring gene long non-coding RNA:CR44489 Neighboring gene Fasciclin 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44486

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An early role for the Drosophila melanogaster male seminal protein Acp36DE in female sperm storage. Bloch Qazi MC, et al. J Exp Biol, 2003 Oct. PMID 12939382
    2. Localization of the Drosophila male accessory gland protein Acp36DE in the mated female suggests a role in sperm storage. Bertram MJ, et al. Insect Biochem Mol Biol, 1996 Sep-Oct. PMID 9014340
    3. Cleavage of the Drosophila seminal protein Acp36DE in mated females enhances its sperm storage activity. Avila FW, et al. J Insect Physiol, 2017 Aug. PMID 28676322, Free PMC Article
    4. Sperm competition: defining the rules of engagement. Karr TL, et al. Curr Biol, 1999 Oct 21. PMID 10531020
    5. The role of male accessory gland protein Acp36DE in sperm competition in Drosophila melanogaster. Chapman T, et al. Proc Biol Sci, 2000 Jun 7. PMID 10885514, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations of Acp36DE's cleavage site that slowed or prevented cleavage of the protein slowed the accumulation of sperm into storage, although they did not affect uterine conformational changes in mated females.
      Title: Cleavage of the Drosophila seminal protein Acp36DE in mated females enhances its sperm storage activity.
    2. Mates of males lacking Acp36DE, which is needed for the accumulation of sperm in the storage organs, fail to complete the full sequence of the conformational changes in the mated female's uterus that occur during and immediately after mating.
      Title: Acp36DE is required for uterine conformational changes in mated Drosophila females.
    3. once sperm storage has initiated, Acp36DE acts as a guidance factor helping subsequent sperm move into storage
      Title: An early role for the Drosophila melanogaster male seminal protein Acp36DE in female sperm storage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mating plug formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity, post-mating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sperm competition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm competition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm storage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    accessory gland protein 36DE
    Names
    36DE accessory gland protein
    Acp36DE-PA
    Acp36DE-PB
    CG7157-PA
    CG7157-PB
    accessory gland peptide 36DE
    accessory gland protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18356047..18359028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299111.2 → NP_001286040.1  accessory gland protein 36DE, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46198, Q9U9Y5, Q9V3R1
      UniProtKB/TrEMBL
      X2J8Y6
      Conserved Domains (1) summary
      PRK13729
      Location:577 → 682
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    2. NM_078870.4 → NP_523594.1  accessory gland protein 36DE, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46198, Q9U9Y5, Q9V3R1
      UniProtKB/TrEMBL
      X2J8Y6
      Related
      FBpp0080607
      Conserved Domains (1) summary
      PRK13729
      Location:577 → 682
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3R1.1 Q9V3R1
    X2J8Y6 X2J8Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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