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    CG42383 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42383provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259729
    Locus tag
    Dmel_CG42383
    See related
    AllianceGenome:FB:FBgn0259729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4556; Dmel\CG42383; eyc; Eyc; p47; p47 NSFL1
    Old locus tag
    Dmel_CG4556
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human UBXN2B (UBX domain protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42383 in Genome Data Viewer
    Location:
    60C8-60C8; 2-106 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24423926..24425102, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20311449..20312625, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z Neighboring gene prominin Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec22 regulates endoplasmic reticulum morphology but not autophagy and is required for eye development in Drosophila. Zhao X, et al. J Biol Chem, 2015 Mar 20. PMID 25670863, Free PMC Article
    2. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    3. Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Sang TK, et al. Development, 2002 Jan. PMID 11782408
    4. Membrane trafficking in Drosophila wing and eye development. Stewart BA. Semin Cell Dev Biol, 2002 Apr. PMID 12127141
    5. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane reassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42383-PA
    eyes closed

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24423926..24425102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079123.2 → NP_523847.2  uncharacterized protein Dmel_CG42383 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523847.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U9C9, Q9W175
      Related
      FBpp0289272, FBtr0299995
      Conserved Domains (3) summary
      cd01770
      Location:257 → 336
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:155 → 242
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
      cd14273
      Location:10 → 39
      UBA_TAP-C_like; UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W175 Q9W175

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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