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    gol goliath [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    golprovided by FlyBase
    Official Full Name
    goliathprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004919
    Locus tag
    Dmel_CG2679
    See related
    AllianceGenome:FB:FBgn0004919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-G1; CG2679; dgol; Dmel\CG2679; g1; Gol; meso
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in mesoderm formation and protein ubiquitination. Located in endosome. Is expressed in several structures, including dorsal pharyngeal muscle primordium; larval muscle system; pharyngeal muscle cell; somatic muscle primordium; and visceral muscle primordium. Orthologous to several human genes including RNF150 (ring finger protein 150). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gol in Genome Data Viewer
    Location:
    60F3-60F3; 2-107 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25072627..25084347, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20960150..20971870, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gooseberry-neuro Neighboring gene transfer RNA:Alanine-CGC 1-1 Neighboring gene transfer RNA:Alanine-CGC 1-2 Neighboring gene transfer RNA:Alanine-CGC 1-3 Neighboring gene gooseberry Neighboring gene jim lovell Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Bouchard ML, et al. Gene, 1993 Mar 30. PMID 8462875
    2. From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease. Cabana VC, et al. Cells, 2022 Jan 23. PMID 35159190, Free PMC Article
    3. The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo. Côté S, et al. EMBO J, 1987 Sep. PMID 16453795, Free PMC Article
    4. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Miller JP, et al. Neuron, 2010 Jul 29. PMID 20670829, Free PMC Article
    5. Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD. Fu J, et al. Genes Dev, 2016 Aug 1. PMID 27542830, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mesoderm formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    goliath
    Names
    CG2679-PB
    CG2679-PC
    CG2679-PD
    CG2679-PE
    gol-PB
    gol-PC
    gol-PD
    gol-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      25072627..25084347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169829.3 → NP_001163300.1  goliath, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163300.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06003
      Conserved Domains (3) summary
      cd02122
      Location:73 → 217
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:301 → 344
      zf-RING_2; Ring finger domain
      cl11506
      Location:226 → 258
      UPF0233; uncharacterized protein family (UPF0233)

    2. NM_166705.3 → NP_726508.1  goliath, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGX0, Q06003, Q8T0M7, Q9W0W3
      Related
      FBpp0072361
      Conserved Domains (3) summary
      cd02122
      Location:73 → 217
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:301 → 344
      zf-RING_2; Ring finger domain
      cl11506
      Location:226 → 258
      UPF0233; uncharacterized protein family (UPF0233)

    3. NM_001259588.2 → NP_001246517.1  goliath, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K8B7
      Conserved Domains (3) summary
      cd02122
      Location:73 → 217
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:301 → 344
      zf-RING_2; Ring finger domain
      cl11506
      Location:226 → 258
      UPF0233; uncharacterized protein family (UPF0233)

    4. NM_079140.5 → NP_523864.3  goliath, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523864.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K8B7
      Conserved Domains (3) summary
      cd02122
      Location:73 → 217
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:301 → 344
      zf-RING_2; Ring finger domain
      cl11506
      Location:226 → 258
      UPF0233; uncharacterized protein family (UPF0233)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K8B7 A0A0B4K8B7
    Q06003.3 Q06003

    Gene LinkOut

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