wb wing blister [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wbprovided by FlyBase
Official Full Name: wing blisterprovided by FlyBase
Primary source: FLYBASE:FBgn0261563
Locus tag: Dmel_CG42677
See related: AllianceGenome:FB:FBgn0261563
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2; 2Lan; 2]]; A1; alpha1; alpha[[1; BEST:CK02229; BG:DS03792.1; BG:DS03792.2; CG15288; CG32970; CG42677; CK02229; CT35236; DLAM; Dmel\CG42677; fus5; l(2)09437; l(2)34Fb; l(2)br1; l34Fb; LanA1; LanWb; LM-A/alpha2; Wb
Old locus tag: Dmel_CG15288; Dmel_CG32970
Summary: Predicted to be an extracellular matrix structural constituent. Involved in digestive tract mesoderm development; epithelial structure maintenance; and gonad development. Located in basement membrane. Is expressed in several structures, including alary cell; border follicle cell; direct flight muscle precursor cell; female germline cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to several human genes including LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35A3-35A4; 2-50 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14263027..14328262)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14263027..14328262)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins.
Title: Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins.
Wb laminin is an extracellular matrix ligand that is essential for integrin-dependent cellular migration in Drosophila.
Title: Tissue-specific laminin expression facilitates integrin-dependent association of the embryonic wing disc with the trachea in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0188 (e-PCR)
- UniSTS:38485

Dm0012 (e-PCR)
- UniSTS:18343

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestive tract mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: wing blister

Names: CG42677-PB; CG42677-PC; CG42677-PD; CG42677-PE; CG42677-PF; CG42677-PG; D-laminin alpha2; SGP cluster fusion defects 5; alpha laminin; laminin; laminin A2; laminin alpha1,2; laminin alpha[[1,2]]; lamininW; lethal 1 in the black-reduced region; lethal group A1; wb-PB; wb-PC; wb-PD; wb-PE; wb-PF; wb-PG; wing blistered; wingblister

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

14263027..14328262

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165086.3 → NP_723870.1 wing blister, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723870.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IP51, Q9XZC9

Related

FBpp0291871

Conserved Domains (11) summary

pfam03302
Location:953 → 1414

VSP; Giardia variant-specific surface protein

COG0699
Location:1933 → 2267

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:1150 → 1197

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3192 → 3347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00052
Location:1486 → 1611

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1199 → 1247

Laminin_EGF; Laminin EGF domain

pfam00055
Location:164 → 396

Laminin_N; Laminin N-terminal (Domain VI)

pfam02210
Location:2804 → 2944

Laminin_G_2; Laminin G domain

pfam06009
Location:2277 → 2400

Laminin_II; Laminin Domain II

cl22855
Location:407 → 507

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cl22861
Location:2399 → 2492

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_057442.5 → NP_476790.3 wing blister, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476790.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9XZC9, R9PY40

Conserved Domains (8) summary

COG0699
Location:1933 → 2267

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:1150 → 1197

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00052
Location:1486 → 1611

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1199 → 1247

Laminin_EGF; Laminin EGF domain

pfam00055
Location:164 → 396

Laminin_N; Laminin N-terminal (Domain VI)

pfam02210
Location:2804 → 2944

Laminin_G_2; Laminin G domain

pfam06009
Location:2277 → 2400

Laminin_II; Laminin Domain II

cl22861
Location:2399 → 2492

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001201879.2 → NP_001188808.1 wing blister, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188808.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRU0

Conserved Domains (9) summary

COG0699
Location:1125 → 1459

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:342 → 389

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2384 → 2539

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl00348
Location:1186 → 1277

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam00052
Location:678 → 803

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:391 → 439

Laminin_EGF; Laminin EGF domain

pfam02210
Location:1996 → 2136

Laminin_G_2; Laminin G domain

pfam06009
Location:1469 → 1592

Laminin_II; Laminin Domain II

cl22861
Location:1591 → 1684

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001201878.2 → NP_001188807.1 wing blister, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188807.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRU0

Conserved Domains (9) summary

COG0699
Location:1125 → 1459

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:342 → 389

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2384 → 2539

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl00348
Location:1186 → 1277

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam00052
Location:678 → 803

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:391 → 439

Laminin_EGF; Laminin EGF domain

pfam02210
Location:1996 → 2136

Laminin_G_2; Laminin G domain

pfam06009
Location:1469 → 1592

Laminin_II; Laminin Domain II

cl22861
Location:1591 → 1684

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001201880.2 → NP_001188809.1 wing blister, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188809.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRU0

Conserved Domains (9) summary

COG0699
Location:1125 → 1459

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:342 → 389

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2384 → 2539

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl00348
Location:1186 → 1277

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam00052
Location:678 → 803

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:391 → 439

Laminin_EGF; Laminin EGF domain

pfam02210
Location:1996 → 2136

Laminin_G_2; Laminin G domain

pfam06009
Location:1469 → 1592

Laminin_II; Laminin Domain II

cl22861
Location:1591 → 1684

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001201877.2 → NP_001188806.1 wing blister, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188806.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRU0

Conserved Domains (9) summary

COG0699
Location:1125 → 1459

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd00055
Location:342 → 389

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2384 → 2539

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl00348
Location:1186 → 1277

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam00052
Location:678 → 803

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:391 → 439

Laminin_EGF; Laminin EGF domain

pfam02210
Location:1996 → 2136

Laminin_G_2; Laminin G domain

pfam06009
Location:1469 → 1592

Laminin_II; Laminin Domain II

cl22861
Location:1591 → 1684

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...