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    kon kon-tiki [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    konprovided by FlyBase
    Official Full Name
    kon-tikiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032683
    Locus tag
    Dmel_CG10275
    See related
    AllianceGenome:FB:FBgn0032683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10275; CT28869; Dmel\CG10275; Kon; perd
    Summary
    Involved in muscle attachment; positive regulation of filopodium assembly; and sarcomere organization. Located in cell tip; muscle tendon junction; and myofibril. Is expressed in several structures, including dorsal pharyngeal muscle primordium; glial cell; larval muscle cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kon in Genome Data Viewer
    Location:
    36F5-36F6; 2-53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18487747..18503978, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18487747..18503978, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene let-7 Complex Neighboring gene mir-125 stem loop Neighboring gene uncharacterized protein Neighboring gene grindelwald Neighboring gene UDP-glycosyltransferase family 301 member D1 Neighboring gene long non-coding RNA:CR44903 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila. Pérez-Moreno JJ, et al. Front Cell Dev Biol, 2021. PMID 35047493, Free PMC Article
    2. Positional cloning by fast-track SNP-mapping in Drosophila melanogaster. Schnorrer F, et al. Nat Protoc, 2008. PMID 18948975
    3. Latent effects of early-life methylmercury exposure on motor function in Drosophila. Peppriell AE, et al. Neurotoxicol Teratol, 2021 Nov-Dec. PMID 34656729, Free PMC Article
    4. The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila. Pérez-Moreno JJ, et al. J Cell Sci, 2014 Jul 15. PMID 24794494, Free PMC Article
    5. Glial kon/NG2 gene network for central nervous system repair. Losada-Perez M, et al. Neural Regen Res, 2017 Jan. PMID 28250735, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the conserved transmembrane Drosophila proteoglycan Kon-tiki (Kon, also known as Perdido) interacts with the alphaPS2betaPS integrin (alphaPS2 is encoded by inflated and betaPS by myospheroid) to mediate muscle-tendon adhesion.
      Title: Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
    2. Two negative feedback loops with Notch and Pros allow Kon to drive the homeostatic regulation required for central nervous system repair.
      Title: Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki.
    3. propose that Perd regulates projection of myotube processes the myotendinous junction by priming formation of a protein complex through its intracellular interaction with Grip and the tendon cell-expressed laminin-binding alpha PS1-beta PS integrin
      Title: The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo.
    4. Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection.
      Title: The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle attachment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in costamere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kon-tiki
    Names
    CG10275-PB
    CG10275-PC
    CG10275-PD
    Kon-tiki
    NG2-like
    kon-PB
    kon-PC
    kon-PD
    kontiki
    perdido

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18487747..18503978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273610.1 → NP_001260539.1  kon-tiki, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RLX3, Q9VJ82
      Conserved Domains (2) summary
      cd00110
      Location:211 → 365
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:1436 → 1578
      Cadherin_3; Cadherin-like

    2. NM_136037.4 → NP_609881.3  kon-tiki, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609881.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RLX3, Q9VJ82
      Conserved Domains (2) summary
      cd00110
      Location:211 → 365
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:1436 → 1578
      Cadherin_3; Cadherin-like

    3. NM_001273611.1 → NP_001260540.1  kon-tiki, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RLX3, Q9VJ82
      Conserved Domains (2) summary
      cd00110
      Location:211 → 365
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:1436 → 1578
      Cadherin_3; Cadherin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960X3 Q960X3
    Q9VJ82 Q9VJ82

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