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    eif-3.L Eukaryotic translation initiation factor 3 subunit L [ Caenorhabditis elegans ]

    Gene ID: 24104220, updated on 4-Jan-2025

    Summary

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    Official Symbol
    eif-3.L
    Official Full Name
    Eukaryotic translation initiation factor 3 subunit L
    Primary source
    WormBase:WBGene00015920
    Locus tag
    CELE_C17G10.9
    See related
    AllianceGenome:WB:WBGene00015920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and pharynx. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See eif-3.L in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (5619584..5622483, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Hydroxysteroid dehydrogenase-like protein 2 Neighboring gene Nuclear protein localization protein 4 homolog 2 Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo Neighboring gene ubiquitinyl hydrolase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans. Cattie DJ, et al. PLoS Genet, 2016 Sep. PMID 27690135, Free PMC Article
    2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 3 subunit L
    NP_001293503.1
    • Confirmed by transcript evidence
    NP_001293504.1
    • Confirmed by transcript evidence
    NP_001335534.1
    • Confirmed by transcript evidence
    NP_001368627.1
    • Confirmed by transcript evidence
    NP_001368628.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5619584..5622483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306574.2 → NP_001293503.1  Eukaryotic translation initiation factor 3 subunit L [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQD4, Q95QW0
      Conserved Domains (1) summary
      pfam10255
      Location:117 → 522
      Paf67; RNA polymerase I-associated factor PAF67

    2. NM_001381425.2 → NP_001368628.1  Eukaryotic translation initiation factor 3 subunit L [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYR1
      Conserved Domains (1) summary
      pfam10255
      Location:72 → 480
      Paf67; RNA polymerase I-associated factor PAF67

    3. NM_001306575.4 → NP_001293504.1  Eukaryotic translation initiation factor 3 subunit L [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QW0
      Conserved Domains (1) summary
      pfam10255
      Location:115 → 520
      Paf67; RNA polymerase I-associated factor PAF67

    4. NM_001348631.4 → NP_001335534.1  Eukaryotic translation initiation factor 3 subunit L [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYP6
      Conserved Domains (1) summary
      pfam10255
      Location:118 → 523
      Paf67; RNA polymerase I-associated factor PAF67

    5. NM_001381424.1 → NP_001368627.1  Eukaryotic translation initiation factor 3 subunit L [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYP7
      Conserved Domains (1) summary
      pfam10255
      Location:72 → 477
      Paf67; RNA polymerase I-associated factor PAF67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95QW0.1

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