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    irg-8 CUB_2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    irg-8
    Official Full Name
    CUB_2 domain-containing protein
    Primary source
    WormBase:WBGene00022645
    Locus tag
    CELE_ZK6.11
    See related
    AllianceGenome:WB:WBGene00022645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Located in membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See irg-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (415870..417706, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Downstream Of DAF-16 (regulated by DAF-16);GH131_N domain-containing protein;IgGFc_binding domain-containing protein Neighboring gene UNC93-like protein MFSD11 Neighboring gene Downstream Of DAF-16 (regulated by DAF-16)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia. Radeke LJ, et al. BMC Microbiol, 2020 Jun 19. PMID 32560629, Free PMC Article
    2. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
    3. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
    4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    located_in membrane raft HDA PubMed 

    General protein information

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    Preferred Names
    CUB_2 domain-containing protein
    NP_001024314.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      415870..417706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029143.4 → NP_001024314.1  CUB_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0Q1, Q6EZG8
      Conserved Domains (1) summary
      pfam03409
      Location:44 → 373
      Glycoprotein; Transmembrane glycoprotein
    Nucleotide Protein
    Heading Accession and Version

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