Arhgef5 Rho guanine nucleotide exchange factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef5provided by MGI
Official Full Name: Rho guanine nucleotide exchange factor 5provided by MGI
Primary source: MGI:MGI:1858952
See related: Ensembl:ENSMUSG00000033542 AllianceGenome:MGI:1858952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tim1; 2210412D05Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid dendritic cell chemotaxis; and positive regulation of podosome assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 16.0), placenta adult (RPKM 11.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 21.15 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (43242578..43266250)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (43265644..43289320)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration
Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of podosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 5

Names: Rho guanine nucleotide exchange factor (GEF) 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417622.1 → NP_001404551.1 rho guanine nucleotide exchange factor 5

Status: VALIDATED

Source sequence(s)

AC153885, AC158671

UniProtKB/Swiss-Prot

E9Q7D5, Q8R172, Q922T1
NM_133674.2 → NP_598435.1 rho guanine nucleotide exchange factor 5

See identical proteins and their annotated locations for NP_598435.1

Status: VALIDATED

Source sequence(s)

AC153885, AC158671

Consensus CDS

CCDS51759.1

UniProtKB/Swiss-Prot

E9Q7D5, Q8R172, Q922T1

Related

ENSMUSP00000031750.7, ENSMUST00000031750.14

Conserved Domains (5) summary

cd11940
Location:1498 → 1552

SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19

PHA03247
Location:398 → 949

PHA03247; large tegument protein UL36; Provisional

cd01221
Location:1362 → 1488

PH_ephexin; Ephexin Pleckstrin homology (PH) domain

pfam00621
Location:1164 → 1340

RhoGEF; RhoGEF domain

pfam15441
Location:1 → 477

ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35