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    T13C5.6 Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T13C5.6
    Official Full Name
    Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
    Primary source
    WormBase:WBGene00020486
    Locus tag
    CELE_T13C5.6
    See related
    AllianceGenome:WB:WBGene00020486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sphingosine-1-phosphate phosphatase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be active in membrane. Orthologous to human PLPP6 (phospholipid phosphatase 6) and PLPP7 (phospholipid phosphatase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T13C5.6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (6206362..6207687, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene 3-ketosteroid oxygenase;Cytochrome P450 Neighboring gene Beta carbonic anhydrase 1 Neighboring gene Mitochondrial fission process protein 1 Neighboring gene ncRNA Neighboring gene EB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
    NP_509040.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6206362..6207687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076639.6 → NP_509040.2  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509040.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22461
      Conserved Domains (1) summary
      cd03391
      Location:8 → 171
      PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...
    Nucleotide Protein
    Heading Accession and Version

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