Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfatc1provided by MGI
Official Full Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1provided by MGI
Primary source: MGI:MGI:102469
See related: Ensembl:ENSMUSG00000033016 AllianceGenome:MGI:102469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; leukocyte differentiation; and negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; genitourinary system; heart; hemolymphoid system; and limb mesenchyme. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 23.0), thymus adult (RPKM 14.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 53.66 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (80649418..80756286, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (80606205..80713071, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular C1qbp inhibits myogenesis by suppressing NFATc1.
Title: Extracellular C1qbp inhibits myogenesis by suppressing NFATc1.
NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling.
Title: NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling.
The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function.
Title: The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function.
The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression.
Title: The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression.
Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis.
Title: Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis.
Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation.
Title: Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Title: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
Title: Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
SIRT3-and FAK-mediated acetylation-phosphorylation crosstalk of NFATc1 regulates N[epsilon]-carboxymethyl-lysine-induced vascular calcification in diabetes mellitus.
Title: SIRT3-and FAK-mediated acetylation-phosphorylation crosstalk of NFATc1 regulates N(ε)-carboxymethyl-lysine-induced vascular calcification in diabetes mellitus.
Microglial LRRK2-mediated NFATc1 attenuates alpha-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.
Title: Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.

Submit: New GeneRIF Correction See all GeneRIFs (286)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

01.MMHAP47FLA1.seq (e-PCR)
- UniSTS:122656

01.MMHAP62FLA1.seq (e-PCR)
- UniSTS:122662

Nfatc1 (e-PCR), detects polymorphism
- UniSTS:547645

Nfatc1 (e-PCR), detects polymorphism
- UniSTS:144002

Nfatc1 (e-PCR), detects polymorphism
- UniSTS:499099

AI449492 (e-PCR)
- UniSTS:166109

AF087434 (e-PCR)
- UniSTS:160765

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase p38 binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B-1a B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aortic valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in lymph vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell quiescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in endocardial cushion development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart trabecula morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pulmonary valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hair cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semi-lunar valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transition between fast and slow fiber	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 1

Names: NF-ATc1; NFAT transcription complex cytosolic component; transcription factor NF-ATc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164109.1 → NP_001157581.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 3

See identical proteins and their annotated locations for NP_001157581.1

Status: VALIDATED

Source sequence(s)

AI449492, AK048610, EU887570

Consensus CDS

CCDS89287.1

UniProtKB/TrEMBL

B5B2N5, Q3UME0

Related

ENSMUSP00000158358.2, ENSMUST00000236711.2

Conserved Domains (2) summary

cd07881
Location:417 → 591

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:596 → 696

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001164110.1 → NP_001157582.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 4

See identical proteins and their annotated locations for NP_001157582.1

Status: VALIDATED

Source sequence(s)

AK048610, EU887567

Consensus CDS

CCDS50336.1

UniProtKB/TrEMBL

B5B2N2

Related

ENSMUSP00000129001.2, ENSMUST00000170905.9

Conserved Domains (2) summary

cd07881
Location:417 → 591

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:596 → 696

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001164111.1 → NP_001157583.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 6

See identical proteins and their annotated locations for NP_001157583.1

Status: VALIDATED

Source sequence(s)

BB647702, EU887569

Consensus CDS

CCDS89286.1

UniProtKB/Swiss-Prot

O70345, O88942

UniProtKB/TrEMBL

B5B2N4, Q3UME0

Related

ENSMUSP00000158284.2, ENSMUST00000236310.2

Conserved Domains (2) summary

cd07881
Location:403 → 577

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:582 → 682

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001164112.1 → NP_001157584.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 5

See identical proteins and their annotated locations for NP_001157584.1

Status: VALIDATED

Source sequence(s)

BB647702, EU887572

Consensus CDS

CCDS50335.1

UniProtKB/TrEMBL

B5B2N7

Related

ENSMUSP00000126884.2, ENSMUST00000167977.8

Conserved Domains (2) summary

cd07881
Location:403 → 577

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:582 → 682

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_016791.4 → NP_058071.2 nuclear factor of activated T-cells, cytoplasmic 1 isoform 1

See identical proteins and their annotated locations for NP_058071.2

Status: VALIDATED

Source sequence(s)

AI449492, BB647702, EU887571

Consensus CDS

CCDS29369.1

UniProtKB/Swiss-Prot

O70345, O88942

UniProtKB/TrEMBL

Q3UME0, Q9DBQ6

Related

ENSMUSP00000046312.8, ENSMUST00000035800.8

Conserved Domains (2) summary

cd07881
Location:403 → 577

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:582 → 682

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_198429.2 → NP_940821.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

See identical proteins and their annotated locations for NP_940821.1

Status: VALIDATED

Source sequence(s)

AK048610, EU887568

Consensus CDS

CCDS37873.1

UniProtKB/TrEMBL

Q3UME0, Q6P7T9

Related

ENSMUSP00000077196.5, ENSMUST00000078049.12

Conserved Domains (2) summary

cd07881
Location:417 → 591

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:596 → 696

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

80649418..80756286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161027.1 → XP_036016920.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform X2

UniProtKB/Swiss-Prot

O70345, O88942

UniProtKB/TrEMBL

Q3UME0

Conserved Domains (2) summary

cd07881
Location:425 → 599

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:604 → 704

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036161026.1 → XP_036016919.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform X1

Conserved Domains (3) summary

cd07881
Location:425 → 599

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

PHA03247
Location:704 → 897

PHA03247; large tegument protein UL36; Provisional

cl15674
Location:604 → 704

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036161029.1 → XP_036016922.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform X3

Conserved Domains (3) summary

cd07881
Location:9 → 183

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

PHA03247
Location:288 → 481

PHA03247; large tegument protein UL36; Provisional

cl15674
Location:188 → 288

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...