U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aex-4 t-SNARE protein aex-4 [ Caenorhabditis elegans ]

    Gene ID: 188509, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aex-4
    Official Full Name
    t-SNARE protein aex-4
    Primary source
    WormBase:WBGene00006454
    Locus tag
    CELE_T14G12.2
    See related
    AllianceGenome:WB:WBGene00006454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in positive regulation of defecation and positive regulation of protein secretion. Located in plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See aex-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (3729281..3731961)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-like protein 1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Forkhead box protein fkh-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. Lin-Moore AT, et al. PLoS Genet, 2021 Nov. PMID 34818334, Free PMC Article
    2. PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Zhou KM, et al. Neuron, 2007 Nov 21. PMID 18031683
    3. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Mahoney TR, et al. Proc Natl Acad Sci U S A, 2008 Oct 21. PMID 18852466, Free PMC Article
    4. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Didiano D, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921378
    5. Reversal of a muscle response to GABA during C. elegans male development. Reiner DJ, et al. J Neurosci, 1995 Sep. PMID 7666193, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    t-SNARE protein aex-4
    NP_508641.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3729281..3731961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076240.8 → NP_508641.2  t-SNARE protein aex-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508641.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEN8
      Conserved Domains (1) summary
      cl22856
      Location:173 → 231
      SNARE; SNARE motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEN8.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous