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    bus-18 Lysophosphatidylinositol acyltransferase 10 [ Caenorhabditis elegans ]

    Gene ID: 186277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bus-18
    Official Full Name
    Lysophosphatidylinositol acyltransferase 10
    Primary source
    WormBase:WBGene00044631
    Locus tag
    CELE_F55A11.5
    See related
    AllianceGenome:WB:WBGene00044631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables acyltransferase activity. Involved in morphogenesis of an epithelium and phosphatidylinositol metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including AIY; epithelial cell; excretory gland cell; spermatheca; and vulva. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bus-18 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11773720..11776636)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene GST C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phosphoglycerate mutase family protein Neighboring gene RING-CH-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. Imae R, et al. J Lipid Res, 2012 Mar. PMID 22172515, Free PMC Article
    2. Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. Imae R, et al. Mol Biol Cell, 2010 Sep 15. PMID 20668164, Free PMC Article
    3. The acyltransferase gene bus-1 exhibits conserved and specific expression in nematode rectal cells and reveals pathogen-induced cell swelling. Gravato-Nobre MJ, et al. Dev Dyn, 2008 Dec. PMID 19035336
    4. The hmsHFRS operon of Xenorhabdus nematophila is required for biofilm attachment to Caenorhabditis elegans. Drace K, et al. Appl Environ Microbiol, 2008 Jul. PMID 18515487, Free PMC Article
    5. Caenorhabditis elegans mutants resistant to attachment of Yersinia biofilms. Darby C, et al. Genetics, 2007 May. PMID 17339204, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified acl-8, -9, and -10, which are closely related to each other, and ipla-1 as strong candidates for genes involved in fatty acid remodeling at the sn-1 position of phosphatidylinositol.
      Title: Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lysophosphatidylinositol acyltransferase 10
    NP_505971.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11773720..11776636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073570.4 → NP_505971.2  Lysophosphatidylinositol acyltransferase 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505971.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20800
      Conserved Domains (2) summary
      cd07990
      Location:63 → 257
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:249 → 329
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20800.2

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