U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ctl-1 Catalase-2 [ Caenorhabditis elegans ]

    Gene ID: 259738, updated on 14-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ctl-1
    Official Full Name
    Catalase-2
    Primary source
    WormBase:WBGene00000830
    Locus tag
    CELE_Y54G11A.6
    See related
    AllianceGenome:WB:WBGene00000830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables catalase activity. Predicted to be involved in hydrogen peroxide catabolic process and response to hydrogen peroxide. Predicted to be active in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Jan 2025]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ctl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (14303568..14306260, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 38 Neighboring gene Tetratricopeptide repeat protein 38 Neighboring gene Peroxisomal catalase 1 Neighboring gene Catalase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Immunological detection of alkaline-diaminobenzidine-negativeperoxisomes of the nematode Caenorhabditis elegans purification and unique pH optima of peroxisomal catalase. Togo SH, et al. Eur J Biochem, 2000 Mar. PMID 10691967
    2. Glyphosate-based herbicides modulate oxidative stress response in the nematode Caenorhabditis elegans. Kronberg MF, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Dec. PMID 30142450
    3. The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Kampkötter A, et al. Pharmacol Res, 2007 Feb. PMID 17207635
    4. Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Blaise BJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18077412, Free PMC Article
    5. Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans. Guo SY, et al. Brain Res Bull, 2022 Nov. PMID 36191729

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the oxidative stress response genes sod-3 and ctl-2 are required for DAF-16-mediated resistance to Enterococcus faecalis
      Title: Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans.
    2. cytosolic catalase CTL-1 has no effect on either nematode aging or egg laying capacity
      Title: Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Catalase-2
    NP_496979.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14303568..14306260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064578.6 → NP_496979.2  Catalase-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496979.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18193, O61235, Q9XVZ4
      Conserved Domains (2) summary
      cd08156
      Location:64 → 492
      catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
      COG0753
      Location:21 → 492
      KatE; Catalase [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61235.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools