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    swd-2.1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swd-2.1
    Official Full Name
    Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
    Primary source
    WormBase:WBGene00016373
    Locus tag
    CELE_C33H5.6
    See related
    AllianceGenome:WB:WBGene00016373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA-templated transcription termination. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See swd-2.1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (7776025..7778022)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rentinal Degeneration 3-Like Neighboring gene Host cell factor homolog hcf-1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene RNA polymerase II-associated protein 3 Neighboring gene Exocyst complex component 5 Neighboring gene Transmembrane protein 65 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels. Petty E, et al. PLoS One, 2011. PMID 21998734, Free PMC Article
    2. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development. Simonet T, et al. Dev Biol, 2007 Dec 1. PMID 17967446
    3. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
    NP_501281.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7776025..7778022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068880.3 → NP_501281.2  Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501281.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18404
      Conserved Domains (2) summary
      sd00039
      Location:33 → 67
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:28 → 272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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