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    glh-2 ATP-dependent RNA helicase glh-2 [ Caenorhabditis elegans ]

    Gene ID: 172361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glh-2
    Official Full Name
    ATP-dependent RNA helicase glh-2
    Primary source
    WormBase:WBGene00001599
    Locus tag
    CELE_C55B7.1
    See related
    AllianceGenome:WB:WBGene00001599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables JUN kinase binding activity and RNA helicase activity. Involved in germ cell development and post-embryonic development. Located in P granule. Is expressed in germ line and gonad. Orthologous to human DDX4 (DEAD-box helicase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glh-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6513928..6517507)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Neighboring gene Protein OSCP1 Neighboring gene C2H2-type domain-containing protein;Transcription factor che-1 Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class Z

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans. Gruidl ME, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943022, Free PMC Article
    2. Germ-line determination in Caenorhabditis and Ascaris: will a helicase begin to unravel the mystery? Roussell D, et al. Parasitol Today, 1994 Mar. PMID 15275493
    3. Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins. Spike C, et al. Genetics, 2008 Apr. PMID 18430929, Free PMC Article
    4. P granules extend the nuclear pore complex environment in the C. elegans germ line. Updike DL, et al. J Cell Biol, 2011 Mar 21. PMID 21402789, Free PMC Article
    5. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275536, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase glh-2
    NP_491876.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6513928..6517507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059475.6 → NP_491876.1  ATP-dependent RNA helicase glh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27376, Q966L9
      Conserved Domains (6) summary
      PTZ00368
      Location:373 → 508
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      PRK01297
      Location:459 → 924
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd00268
      Location:554 → 763
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00098
      Location:282 → 299
      zf-CCHC; Zinc knuckle
      pfam00271
      Location:790 → 912
      Helicase_C; Helicase conserved C-terminal domain
      pfam16210
      Location:69 → 177
      Keratin_2_tail; Keratin type II cytoskeletal 1 tail
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q966L9.1

    Gene LinkOut

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