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    Y43C5A.2 Fibrinogen C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y43C5A.2
    Official Full Name
    Fibrinogen C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00012782
    Locus tag
    CELE_Y43C5A.2
    See related
    AllianceGenome:WB:WBGene00012782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in alcohol dependence; cardiovascular system disease (multiple); congenital afibrinogenemia; end stage renal disease; and hereditary angioedema. Orthologous to human ANGPT1 (angiopoietin 1) and FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y43C5A.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (10269883..10272701)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group D Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fibrinogen C-terminal domain-containing protein
    NP_501883.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10269883..10272701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069482.7 → NP_501883.1  Fibrinogen C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXE9
      Conserved Domains (1) summary
      cd00087
      Location:196 → 438
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version

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