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    imph-1 K Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    imph-1
    Official Full Name
    K Homology domain-containing protein
    Primary source
    WormBase:WBGene00010908
    Locus tag
    CELE_M88.5
    See related
    AllianceGenome:WB:WBGene00010908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in nervous system development. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1); IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2); and IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See imph-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (4553616..4560438)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PID domain-containing protein Neighboring gene ncRNA Neighboring gene P-granule-associated novel protein 1 Neighboring gene Malonyl-CoA decarboxylase, mitochondrial Neighboring gene Isocitrate dehydrogenase [NAD] subunit, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient CRISPR/Cas9 mediated large insertions using long single-stranded oligonucleotide donors in C. elegans. Eroglu M, et al. FEBS J, 2023 Sep. PMID 37254814
    2. Identification of proteins and miRNAs that specifically bind an mRNA in vivo. Theil K, et al. Nat Commun, 2019 Sep 16. PMID 31527589, Free PMC Article
    3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    4. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein
    NP_001022695.1
    • Confirmed by transcript evidence
    NP_001022696.1
    • Partially confirmed by transcript evidence
    NP_001263700.1
    • Confirmed by transcript evidence
    NP_001263701.1
    • Partially confirmed by transcript evidence
    NP_001382732.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4553616..4560438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276771.3 → NP_001263700.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FE02
      Conserved Domains (3) summary
      smart00322
      Location:313 → 384
      KH; K homology RNA-binding domain
      cd00105
      Location:400 → 477
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:569 → 612
      KH_1; KH domain

    2. NM_001395829.1 → NP_001382732.1  K Homology domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9MHE6
      Conserved Domains (1) summary
      smart00322
      Location:147 → 218
      KH; K homology RNA-binding domain

    3. NM_001027524.7 → NP_001022695.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21605
      Conserved Domains (3) summary
      smart00322
      Location:313 → 384
      KH; K homology RNA-binding domain
      cd00105
      Location:400 → 477
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:543 → 586
      KH_1; KH domain

    4. NM_001027525.5 → NP_001022696.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6A582
      Conserved Domains (3) summary
      smart00322
      Location:189 → 260
      KH; K homology RNA-binding domain
      cd00105
      Location:276 → 353
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:419 → 462
      KH_1; KH domain

    5. NM_001276772.3 → NP_001263701.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ERX1
      Conserved Domains (3) summary
      smart00322
      Location:189 → 260
      KH; K homology RNA-binding domain
      cd00105
      Location:276 → 353
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:445 → 488
      KH_1; KH domain
    Nucleotide Protein
    Heading Accession and Version

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