rap-2 small monomeric GTPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rap-2
Official Full Name: small monomeric GTPase
Primary source: WormBase:WBGene00004308
Locus tag: CELE_C25D7.7
See related: AllianceGenome:WB:WBGene00004308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in collagen and cuticulin-based cuticle development and epidermis development. Predicted to be located in recycling endosome membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to several human genes including RAP2A (RAP2A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rap-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (15061488..15064087, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLX-1 suppresses local RAP-2 activity. Excessive ectopic synapse formation in mig-15 mutants causes a severe synaptic tiling defect. Conversely, overexpression of mig-15 strongly inhibited synapse formation, suggesting that mig-15 is a negative regulator of synapse formation.
Title: Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25D7.7 (e-PCR)
- UniSTS:319067

C25D7.9 (e-PCR)
- UniSTS:315597

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen and cuticulin-based cuticle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small monomeric GTPase

NP_506707.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15061488..15064087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074306.3 → NP_506707.2 small monomeric GTPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506707.2

Status: REVIEWED

UniProtKB/TrEMBL

O17599

Conserved Domains (2) summary

cd04176
Location:16 → 165

Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

smart00173
Location:16 → 165

RAS; Ras subfamily of RAS small GTPases