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    ITSN2 intersectin 2 [ Homo sapiens (human) ]

    Gene ID: 50618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ITSN2provided by HGNC
    Official Full Name
    intersectin 2provided by HGNC
    Primary source
    HGNC:HGNC:6184
    See related
    Ensembl:ENSG00000198399 MIM:604464; AllianceGenome:HGNC:6184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWA; SWAP; SH3D1B; SH3P18; PRO2015
    Summary
    This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ITSN2 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24202864..24361368, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24237561..24395986, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24425733..24583405, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene uncharacterized LOC105374328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15429 Neighboring gene family with sequence similarity 228 member A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:24475575-24476774 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11230 Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 9937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24623030-24623530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625230-24625736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625737-24626243 Neighboring gene uncharacterized LOC105374329 Neighboring gene NANOG hESC enhancer GRCh37_chr2:24679828-24680425 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904 Neighboring gene Sharpr-MPRA regulatory region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11232 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24714093-24714251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11233 Neighboring gene MPRA-validated peak3621 silencer Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, 5S ribosomal pseudogene 88

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human Intersectin-2L C2 domain. Zhang W, et al. Biochem Biophys Res Commun, 2013 Feb 1. PMID 23274495
    2. Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain. Seifert M, et al. Oncol Rep, 2007 May. PMID 17390067
    3. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. Rodriguez-Fraticelli AE, et al. J Cell Biol, 2010 May 17. PMID 20479469, Free PMC Article
    4. Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization. Klein IK, et al. J Biol Chem, 2009 Sep 18. PMID 19622753, Free PMC Article
    5. Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation. Ding X, et al. BMB Rep, 2012 Mar. PMID 22449706

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
      Title: Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
    2. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis.
      Title: ITSN2L Interacts with and Negatively Regulates RABEP1.
    3. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins.
      Title: Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.
    4. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
      Title: Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
    5. The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42.
      Title: Crystal structure of human Intersectin-2L C2 domain.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
    7. ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane.
      Title: Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.
    8. We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2).
      Title: The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.
    9. ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function.
      Title: Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.
    10. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2.
      Title: Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of intersectin 2 (ITSN2; SH3P18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intersectin-2
    Names
    SH3 domain-containing protein 1B
    SH3P18-like WASP-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029516.1 RefSeqGene

      Range
      4993..162665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348181.2 → NP_001335110.1  intersectin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:1541 → 1675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:1 → 93
      EH; Eps15 homology domain
      cd11988
      Location:745 → 801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888 → 939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:971 → 1022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1043 → 1101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1116 → 1169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1200 → 1380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76 → 168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801 → 888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1398 → 1540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332 → 742
      Neuromodulin_N; Gap junction protein N-terminal region

    2. NM_001348182.2 → NP_001335111.1  intersectin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:1515 → 1649
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:719 → 775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862 → 913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945 → 996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1017 → 1075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1090 → 1143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1174 → 1354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:775 → 862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1372 → 1514
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377 → 719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126 → 200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    3. NM_001348183.2 → NP_001335112.1  intersectin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:732 → 788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875 → 926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:958 → 1009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1030 → 1088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1103 → 1156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:90 → 182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788 → 875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377 → 727
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001348184.2 → NP_001335113.1  intersectin-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:1 → 93
      EH; Eps15 homology domain
      cd11988
      Location:718 → 774
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:861 → 912
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:944 → 995
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1016 → 1074
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1089 → 1142
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:76 → 168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:774 → 861
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:363 → 713
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001348185.2 → NP_001335114.1  intersectin-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:746 → 802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889 → 940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:972 → 1023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1044 → 1102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1117 → 1170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:802 → 889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl26511
      Location:346 → 743
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27427
      Location:126 → 200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    6. NM_001348186.2 → NP_001335115.1  intersectin-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009228
      UniProtKB/TrEMBL
      Q53TK4
      Conserved Domains (9) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:719 → 775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862 → 913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945 → 996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1017 → 1075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1090 → 1143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:775 → 862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377 → 719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126 → 200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    7. NM_006277.3 → NP_006268.2  intersectin-2 isoform 1

      See identical proteins and their annotated locations for NP_006268.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as ITSN2-L, encodes the longest isoform (1).
      Source sequence(s)
      AC008073, AC009228, AF182198, BC146779, DA382952
      Consensus CDS
      CCDS1710.2
      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000347244.4, ENST00000355123.9
      Conserved Domains (11) summary
      PTZ00121
      Location:346 → 756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1214 → 1394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1412 → 1555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91 → 184
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    8. NM_019595.4 → NP_062541.3  intersectin-2 isoform 3

      See identical proteins and their annotated locations for NP_062541.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 3) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC008073, AC009228, AF182198, AF182199, BC146779, DA382952
      Consensus CDS
      CCDS1711.2
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000354561.2, ENST00000361999.7
      Conserved Domains (12) summary
      cd08375
      Location:1528 → 1662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:732 → 788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875 → 926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:958 → 1009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1030 → 1088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1103 → 1156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1187 → 1367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90 → 182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788 → 875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1385 → 1527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377 → 727
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_147152.3 → NP_671494.2  intersectin-2 isoform 2

      See identical proteins and their annotated locations for NP_671494.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as ITSN2-S1, has an alternate 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC009228, AF038189, AF182199, DA382952
      Consensus CDS
      CCDS46230.1
      UniProtKB/TrEMBL
      Q53TK4
      Related
      ENSP00000384499.3, ENST00000406921.7
      Conserved Domains (13) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam08496
      Location:692 → 757
      Peptidase_S49_N; Peptidase family S49 N-terminal
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:387 → 741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:454 → 465
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379 → 484
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24202864..24361368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444586.1 → XP_047300542.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8

    2. XM_047444582.1 → XP_047300538.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8

    3. XM_024452933.2 → XP_024308701.1  intersectin-2 isoform X3

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:1542 → 1676
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:746 → 802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889 → 940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:972 → 1023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1044 → 1102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1117 → 1170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1201 → 1381
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90 → 182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:802 → 889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1399 → 1541
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346 → 743
      Neuromodulin_N; Gap junction protein N-terminal region

    4. XM_024452934.2 → XP_024308702.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:1528 → 1662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:732 → 788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875 → 926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:958 → 1009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1030 → 1088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1103 → 1156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1187 → 1367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90 → 182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788 → 875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1385 → 1527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377 → 727
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_024452931.2 → XP_024308699.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (11) summary
      PTZ00121
      Location:346 → 756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1214 → 1394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1412 → 1555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91 → 184
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    6. XM_047444584.1 → XP_047300540.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A6H8W8

    7. XM_047444583.1 → XP_047300539.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8

    8. XM_024452930.2 → XP_024308698.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (11) summary
      PTZ00121
      Location:346 → 756
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1214 → 1394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16652
      Location:1412 → 1555
      PH_13; Pleckstrin homology domain
      cd21577
      Location:91 → 184
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    9. XM_024452932.2 → XP_024308700.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A6H8W8
      Conserved Domains (12) summary
      cd08375
      Location:1541 → 1675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:1 → 93
      EH; Eps15 homology domain
      cd11988
      Location:745 → 801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888 → 939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:971 → 1022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1043 → 1101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1116 → 1169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1200 → 1380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76 → 168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801 → 888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1398 → 1540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332 → 742
      Neuromodulin_N; Gap junction protein N-terminal region

    10. XM_047444585.1 → XP_047300541.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A6H8W8

    11. XM_024452937.2 → XP_024308705.1  intersectin-2 isoform X9

      Conserved Domains (9) summary
      cd08375
      Location:787 → 921
      C2_Intersectin; C2 domain present in Intersectin
      cd11990
      Location:134 → 185
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:217 → 268
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:289 → 347
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:362 → 415
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:446 → 626
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:47 → 134
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:644 → 786
      PH_13; Pleckstrin homology domain
      cl17036
      Location:15 → 47
      SH3; Src Homology 3 domain superfamily

    12. XM_047444587.1 → XP_047300543.1  intersectin-2 isoform X5

      UniProtKB/TrEMBL
      A6H8W8

    13. XM_047444590.1 → XP_047300546.1  intersectin-2 isoform X8

      UniProtKB/TrEMBL
      Q53TK4

    14. XM_047444591.1 → XP_047300547.1  intersectin-2 isoform X8

      UniProtKB/TrEMBL
      Q53TK4

    15. XM_047444588.1 → XP_047300544.1  intersectin-2 isoform X6

      UniProtKB/TrEMBL
      Q53TK4

    16. XM_047444589.1 → XP_047300545.1  intersectin-2 isoform X7

      UniProtKB/TrEMBL
      Q53TK4

    17. XM_047444592.1 → XP_047300548.1  intersectin-2 isoform X10

    18. XM_047444594.1 → XP_047300550.1  intersectin-2 isoform X12

    19. XM_047444593.1 → XP_047300549.1  intersectin-2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24237561..24395986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342321.1 → XP_054198296.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8

    2. XM_054342318.1 → XP_054198293.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8

    3. XM_054342319.1 → XP_054198294.1  intersectin-2 isoform X3

      UniProtKB/TrEMBL
      A6H8W8

    4. XM_054342322.1 → XP_054198297.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      A6H8W8

    5. XM_054342317.1 → XP_054198292.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8

    6. XM_054342316.1 → XP_054198291.1  intersectin-2 isoform X1

      UniProtKB/Swiss-Prot
      O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
      UniProtKB/TrEMBL
      A6H8W8

    7. XM_054342320.1 → XP_054198295.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A6H8W8

    8. XM_054342329.1 → XP_054198304.1  intersectin-2 isoform X9

    9. XM_054342328.1 → XP_054198303.1  intersectin-2 isoform X9

    10. XM_054342323.1 → XP_054198298.1  intersectin-2 isoform X5

      UniProtKB/TrEMBL
      A6H8W8

    11. XM_054342326.1 → XP_054198301.1  intersectin-2 isoform X8

      UniProtKB/TrEMBL
      Q53TK4

    12. XM_054342327.1 → XP_054198302.1  intersectin-2 isoform X8

      UniProtKB/TrEMBL
      Q53TK4

    13. XM_054342324.1 → XP_054198299.1  intersectin-2 isoform X6

      UniProtKB/TrEMBL
      Q53TK4

    14. XM_054342325.1 → XP_054198300.1  intersectin-2 isoform X7

      UniProtKB/TrEMBL
      Q53TK4

    15. XM_054342330.1 → XP_054198305.1  intersectin-2 isoform X10

    16. XM_054342332.1 → XP_054198307.1  intersectin-2 isoform X12

    17. XM_054342331.1 → XP_054198306.1  intersectin-2 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZM3.3 GenPept UniProtKB/Swiss-Prot:Q9NZM3

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