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    HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens (human) ]

    Gene ID: 3191, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HNRNPLprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
    Primary source
    HGNC:HGNC:5045
    See related
    Ensembl:ENSG00000104824 MIM:603083; AllianceGenome:HGNC:5045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPL; hnRNP-L; P/OKcl.14
    Summary
    Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HNRNPL in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38836370..38852347, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41640403..41656404, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39327010..39342987, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 4 Neighboring gene MPRA-validated peak3474 silencer Neighboring gene uncharacterized LOC124904712 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:39314813-39315370 Neighboring gene enoyl-CoA hydratase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39333551-39334051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39338887-39339825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39339826-39340763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39343185-39343829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10587 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39350790-39350958 Neighboring gene Sharpr-MPRA regulatory region 3140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39356343-39356918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360061-39360631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360661-39361267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39361268-39361873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10589 Neighboring gene Ras and Rab interactor like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14603 Neighboring gene sirtuin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39384205-39384706

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Heterogeneous nuclear ribonucleoprotein L facilitates recruitment of 53BP1 and BRCA1 at the DNA break sites induced by oxaliplatin in colorectal cancer. Hu W, et al. Cell Death Dis, 2019 Jul 18. PMID 31320608, Free PMC Article
    2. HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1. Zhao Y, et al. Pathol Res Pract, 2021 Feb. PMID 33418347
    3. Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. Guang S, et al. Mol Cell Biol, 2005 Aug. PMID 16024770, Free PMC Article
    4. Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression. Shankarling G, et al. Biochem J, 2013 Jul 15. PMID 23646903, Free PMC Article
    5. HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer. Yu X, et al. DNA Cell Biol, 2021 Oct. PMID 34491823

    See all (339) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
      Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
    2. The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
      Title: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
    3. hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
      Title: hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
    4. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
      Title: FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
    5. lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
      Title: lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
    6. HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
      Title: HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
    7. HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
      Title: HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
    8. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
      Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    9. Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
      Title: Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
    10. A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
      Title: A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35509

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein L
    Names
    epididymis secretory sperm binding protein
    hnRNP L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005335.2 → NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

      See identical proteins and their annotated locations for NP_001005335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AB044547, AC008982, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
      Consensus CDS
      CCDS33016.1
      UniProtKB/TrEMBL
      M0QXS5
      Related
      ENSP00000470231.1, ENST00000600873.5
      Conserved Domains (1) summary
      TIGR01649
      Location:1 → 454
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    2. NM_001385651.1 → NP_001372580.1  heterogeneous nuclear ribonucleoprotein L isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a retained intron compared to variant 1. The encoded isoform (c) is longer than isoform a
      Source sequence(s)
      AC008982
      UniProtKB/TrEMBL
      A0A3B3ITJ4, A0AAG2TNG9
      Related
      ENSP00000497920.2, ENST00000647557.2
      Conserved Domains (1) summary
      TIGR01649
      Location:100 → 624
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    3. NM_001533.3 → NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

      See identical proteins and their annotated locations for NP_001524.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AB044547, AC008982
      Consensus CDS
      CCDS33015.1
      UniProtKB/Swiss-Prot
      A6ND69, A6NIT8, P14866, Q9H3P3
      UniProtKB/TrEMBL
      M0QXS5
      Related
      ENSP00000221419.4, ENST00000221419.10
      Conserved Domains (1) summary
      TIGR01649
      Location:100 → 587
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      38836370..38852347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438739.1 → XP_047294695.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    2. XM_011526888.3 → XP_011525190.1  heterogeneous nuclear ribonucleoprotein L isoform X2

      UniProtKB/TrEMBL
      M0QXS5
      Conserved Domains (5) summary
      cd12699
      Location:322 → 395
      RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      cd12704
      Location:438 → 521
      RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      cd12780
      Location:100 → 179
      RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      TIGR01649
      Location:100 → 526
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:189 → 227
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_047438738.1 → XP_047294694.1  heterogeneous nuclear ribonucleoprotein L isoform X3

      UniProtKB/TrEMBL
      M0QXS5

    4. XM_047438737.1 → XP_047294693.1  heterogeneous nuclear ribonucleoprotein L isoform X1

      UniProtKB/TrEMBL
      M0QXS5
      Related
      ENSP00000469349.1, ENST00000601449.5

    5. XM_047438740.1 → XP_047294696.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p14 PATCHES

      Range
      246042..262019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331966.1 → XP_054187941.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    2. XM_054331963.1 → XP_054187938.1  heterogeneous nuclear ribonucleoprotein L isoform X2

      UniProtKB/TrEMBL
      M0QXS5

    3. XM_054331965.1 → XP_054187940.1  heterogeneous nuclear ribonucleoprotein L isoform X3

      UniProtKB/TrEMBL
      M0QXS5

    4. XM_054331962.1 → XP_054187937.1  heterogeneous nuclear ribonucleoprotein L isoform X1

      UniProtKB/TrEMBL
      M0QXS5

    5. XM_054331961.1 → XP_054187936.1  heterogeneous nuclear ribonucleoprotein L isoform X6

      UniProtKB/TrEMBL
      M0QXS5

    6. XM_054331964.1 → XP_054187939.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    7. XM_054331967.1 → XP_054187942.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41640403..41656404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320805.1 → XP_054176780.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    2. XM_054320802.1 → XP_054176777.1  heterogeneous nuclear ribonucleoprotein L isoform X2

      UniProtKB/TrEMBL
      M0QXS5

    3. XM_054320804.1 → XP_054176779.1  heterogeneous nuclear ribonucleoprotein L isoform X3

      UniProtKB/TrEMBL
      M0QXS5

    4. XM_054320801.1 → XP_054176776.1  heterogeneous nuclear ribonucleoprotein L isoform X1

      UniProtKB/TrEMBL
      M0QXS5

    5. XM_054320800.1 → XP_054176775.1  heterogeneous nuclear ribonucleoprotein L isoform X7

      UniProtKB/TrEMBL
      M0QXS5

    6. XM_054320803.1 → XP_054176778.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    7. XM_054320806.1 → XP_054176781.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14866.2 GenPept UniProtKB/Swiss-Prot:P14866

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