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    SRRM1 serine and arginine repetitive matrix 1 [ Homo sapiens (human) ]

    Gene ID: 10250, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRRM1provided by HGNC
    Official Full Name
    serine and arginine repetitive matrix 1provided by HGNC
    Primary source
    HGNC:HGNC:16638
    See related
    Ensembl:ENSG00000133226 MIM:605975; AllianceGenome:HGNC:16638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    160-KD; POP101; SRM160
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 22.6), prostate (RPKM 22.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRRM1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24643302..24673281)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24481714..24511711)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24969793..24999772)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RCAN family member 3 Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24894097-24894598 Neighboring gene NANOG hESC enhancer GRCh37_chr1:24895749-24896251 Neighboring gene ribosomal protein L26 pseudogene 8 Neighboring gene non-compact myelin associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 435 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24981406-24981591 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 11281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 436 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25041190-25042389 Neighboring gene Sharpr-MPRA regulatory region 6401 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:25050611-25051418 Neighboring gene Sharpr-MPRA regulatory region 445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25056667-25057257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25069429-25070034 Neighboring gene hESC enhancers GRCh37_chr1:25071247-25071852 and GRCh37_chr1:25071853-25072458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 439 Neighboring gene chloride intracellular channel 4 Neighboring gene RNA, U6 small nuclear 1208, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25173940-25174664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 441 Neighboring gene uncharacterized LOC105376876

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Szymczyna BR, et al. Genes Dev, 2003 Feb 15. PMID 12600940, Free PMC Article
    2. The spatial targeting and nuclear matrix binding domains of SRm160. Wagner S, et al. Proc Natl Acad Sci U S A, 2003 Mar 18. PMID 12624182, Free PMC Article
    3. In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. Wagner S, et al. J Cell Biol, 2004 Mar 15. PMID 15024032, Free PMC Article
    4. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. Szymczyna BR, et al. J Biomol NMR, 2002 Mar. PMID 11991360
    5. Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Cheng C, et al. Mol Cell Biol, 2006 Jan. PMID 16354706, Free PMC Article

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We discovered that two factors, SRRM1 and SF3B1, affect not only cis-SAGe chimeras, but also other types of chimeric RNAs in a genome-wide fashion.
      Title: A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.
    2. two contiguous sequences that independently target SRm160 to nuclear matrix sites at splicing speckled domains: amino acids 300-350 and 351-688
      Title: The spatial targeting and nuclear matrix binding domains of SRm160.
    3. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins and plays a role in spliceosome assembly
      Title: Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.
    4. SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner.
      Title: Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion.
    5. found that the majority of proteins identified in SRm160-containing complexes are associated with pre-mRNA processing. Interestingly, SRm160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion
      Title: Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
    6. Data show that SRm160, a splicing coactivator and component of the exon junction complex (EJC) involved in RNA export, has an adenosine triphosphate (ATP)-dependent mobility.
      Title: In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.
    7. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 was determined using reduced dimensionality NMR.
      Title: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human serine/arginine repetitive matrix 1 (SRRM1) at amino acid residues 123-124 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC39488

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing, via transesterification reactions TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 1
    Names
    SR-related nuclear matrix protein of 160 kDa
    Ser/Arg-related nuclear matrix protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303448.2 → NP_001290377.1  serine/arginine repetitive matrix protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001290377.1

      Status: VALIDATED

      Source sequence(s)
      AA744578, AF419855, AK302498, AW958761, BG178896, CX782666
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:618 → 752
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    2. NM_001303449.1 → NP_001290378.1  serine/arginine repetitive matrix protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001290378.1

      Status: VALIDATED

      Source sequence(s)
      AA744578, AF419855, AK302498, AK307419, AW958761, BG178896, CX782666, DC353932
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      pfam01480
      Location:7 → 76
      PWI; PWI domain
      pfam15087
      Location:573 → 702
      DUF4551; Protein of unknown function (DUF4551)

    3. NM_001366565.1 → NP_001353494.1  serine/arginine repetitive matrix protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:523 → 657
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    4. NM_001366566.1 → NP_001353495.1  serine/arginine repetitive matrix protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:523 → 657
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    5. NM_001366567.1 → NP_001353496.1  serine/arginine repetitive matrix protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:521 → 655
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    6. NM_001366568.1 → NP_001353497.1  serine/arginine repetitive matrix protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:537 → 671
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    7. NM_001366569.1 → NP_001353498.1  serine/arginine repetitive matrix protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      Consensus CDS
      CCDS90885.1
      UniProtKB/TrEMBL
      A0A994J7V4, B7Z7U0
      Related
      ENSP00000516158.1, ENST00000705663.1
      Conserved Domains (3) summary
      PHA03247
      Location:414 → 743
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:619 → 753
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    8. NM_001366570.1 → NP_001353499.1  serine/arginine repetitive matrix protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03247
      Location:298 → 658
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    9. NM_001366571.1 → NP_001353500.1  serine/arginine repetitive matrix protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:537 → 671
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    10. NM_001366572.1 → NP_001353501.1  serine/arginine repetitive matrix protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:522 → 656
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    11. NM_001366573.1 → NP_001353502.1  serine/arginine repetitive matrix protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:535 → 669
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    12. NM_001366575.1 → NP_001353504.1  serine/arginine repetitive matrix protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      Consensus CDS
      CCDS90883.1
      UniProtKB/TrEMBL
      A0A994J7H1, B7Z7U0
      Related
      ENSP00000516160.1, ENST00000705682.1
      Conserved Domains (3) summary
      PHA03247
      Location:381 → 741
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:617 → 751
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    13. NM_001366576.1 → NP_001353505.1  serine/arginine repetitive matrix protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (4) summary
      PHA03247
      Location:384 → 713
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:589 → 723
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:121 → 209
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    14. NM_001366577.1 → NP_001353506.1  serine/arginine repetitive matrix protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03307
      Location:590 → 724
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:121 → 209
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    15. NM_001366578.1 → NP_001353507.1  serine/arginine repetitive matrix protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03247
      Location:301 → 630
      PHA03247; large tegument protein UL36; Provisional
      PRK04195
      Location:38 → 126
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    16. NM_001366581.1 → NP_001353510.1  serine/arginine repetitive matrix protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03307
      Location:588 → 722
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:121 → 209
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    17. NM_001366582.1 → NP_001353511.1  serine/arginine repetitive matrix protein 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      Consensus CDS
      CCDS90886.1
      UniProtKB/TrEMBL
      A0A994J4Y3, B7Z7U0
      Related
      ENSP00000516159.1, ENST00000705681.1
      Conserved Domains (2) summary
      PHA03307
      Location:605 → 739
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    18. NM_001366584.1 → NP_001353513.1  serine/arginine repetitive matrix protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:521 → 655
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    19. NM_001366585.1 → NP_001353514.1  serine/arginine repetitive matrix protein 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03247
      Location:331 → 660
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    20. NM_001366586.1 → NP_001353515.1  serine/arginine repetitive matrix protein 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03307
      Location:493 → 627
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:38 → 126
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    21. NM_001366587.1 → NP_001353516.1  serine/arginine repetitive matrix protein 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03307
      Location:507 → 641
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:38 → 126
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    22. NM_001366588.1 → NP_001353517.1  serine/arginine repetitive matrix protein 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:604 → 738
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    23. NM_001366589.1 → NP_001353518.1  serine/arginine repetitive matrix protein 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:603 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    24. NM_001366590.1 → NP_001353519.1  serine/arginine repetitive matrix protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:535 → 669
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    25. NM_001366591.1 → NP_001353520.1  serine/arginine repetitive matrix protein 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03307
      Location:507 → 641
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:38 → 126
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    26. NM_001366592.1 → NP_001353521.1  serine/arginine repetitive matrix protein 1 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (4) summary
      PHA03247
      Location:350 → 709
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:574 → 708
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK04195
      Location:121 → 209
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    27. NM_001366593.1 → NP_001353522.1  serine/arginine repetitive matrix protein 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03247
      Location:331 → 660
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    28. NM_001366594.1 → NP_001353523.1  serine/arginine repetitive matrix protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (3) summary
      PHA03247
      Location:301 → 630
      PHA03247; large tegument protein UL36; Provisional
      PRK04195
      Location:38 → 126
      PRK04195; replication factor C large subunit; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    29. NM_001366595.1 → NP_001353524.1  serine/arginine repetitive matrix protein 1 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686, KU178513
      Consensus CDS
      CCDS90884.1
      UniProtKB/TrEMBL
      A0A0S2Z4Z6, B7Z7U0
      Related
      ENSP00000516157.1, ENST00000705662.1
      Conserved Domains (2) summary
      PHA03307
      Location:620 → 754
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    30. NM_001366596.1 → NP_001353525.1  serine/arginine repetitive matrix protein 1 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      pfam01480
      Location:7 → 76
      PWI; PWI domain
      cl28033
      Location:551 → 685
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    31. NM_001366597.1 → NP_001353526.1  serine/arginine repetitive matrix protein 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      pfam01480
      Location:7 → 76
      PWI; PWI domain
      cl28033
      Location:581 → 715
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    32. NM_001366598.1 → NP_001353527.1  serine/arginine repetitive matrix protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:522 → 656
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    33. NM_001366599.1 → NP_001353528.1  serine/arginine repetitive matrix protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:521 → 655
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    34. NM_001366600.1 → NP_001353529.1  serine/arginine repetitive matrix protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686
      UniProtKB/TrEMBL
      B7Z7U0
      Conserved Domains (2) summary
      PHA03307
      Location:537 → 671
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    35. NM_005839.4 → NP_005830.2  serine/arginine repetitive matrix protein 1 isoform 2

      See identical proteins and their annotated locations for NP_005830.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF048977, BC017315, BC036187, CX782666
      Consensus CDS
      CCDS255.1
      UniProtKB/Swiss-Prot
      O60585, Q5VVN4, Q8IYB3
      UniProtKB/TrEMBL
      A0A0S2Z4W1, B7Z7U0
      Related
      ENSP00000326261.8, ENST00000323848.14
      Conserved Domains (2) summary
      PHA03307
      Location:606 → 740
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    RNA

    1. NR_159378.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    2. NR_159379.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    3. NR_159380.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    4. NR_159382.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    5. NR_159383.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    6. NR_159384.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    7. NR_159385.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    8. NR_159386.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    9. NR_159387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    10. NR_159388.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    11. NR_159389.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    12. NR_159390.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    13. NR_159391.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445648, AL445686

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      24643302..24673281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427188.1 → XP_047283144.1  serine/arginine repetitive matrix protein 1 isoform X14

      UniProtKB/TrEMBL
      B7Z7U0

    2. XM_047427220.1 → XP_047283176.1  serine/arginine repetitive matrix protein 1 isoform X15

      UniProtKB/TrEMBL
      B7Z7U0

    3. XM_047427154.1 → XP_047283110.1  serine/arginine repetitive matrix protein 1 isoform X13

      UniProtKB/TrEMBL
      B7Z7U0

    4. XM_047427247.1 → XP_047283203.1  serine/arginine repetitive matrix protein 1 isoform X16

      UniProtKB/TrEMBL
      B7Z7U0

    5. XM_047427394.1 → XP_047283350.1  serine/arginine repetitive matrix protein 1 isoform X22

    6. XM_047427397.1 → XP_047283353.1  serine/arginine repetitive matrix protein 1 isoform X23

    7. XM_017000013.2 → XP_016855502.1  serine/arginine repetitive matrix protein 1 isoform X3

      UniProtKB/TrEMBL
      B7Z7U0

    8. XM_017000011.2 → XP_016855500.1  serine/arginine repetitive matrix protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z7U0

    9. XM_017000014.2 → XP_016855503.1  serine/arginine repetitive matrix protein 1 isoform X4

      UniProtKB/TrEMBL
      B7Z7U0

    10. XM_017000015.2 → XP_016855504.1  serine/arginine repetitive matrix protein 1 isoform X5

      UniProtKB/TrEMBL
      B7Z7U0

    11. XM_017000012.2 → XP_016855501.1  serine/arginine repetitive matrix protein 1 isoform X2

      UniProtKB/TrEMBL
      B7Z7U0

    12. XM_047427027.1 → XP_047282983.1  serine/arginine repetitive matrix protein 1 isoform X6

      UniProtKB/TrEMBL
      B7Z7U0

    13. XM_047427068.1 → XP_047283024.1  serine/arginine repetitive matrix protein 1 isoform X9

      UniProtKB/TrEMBL
      B7Z7U0

    14. XM_017000017.2 → XP_016855506.1  serine/arginine repetitive matrix protein 1 isoform X7

      UniProtKB/TrEMBL
      B7Z7U0

    15. XM_047427112.1 → XP_047283068.1  serine/arginine repetitive matrix protein 1 isoform X10

      UniProtKB/TrEMBL
      B7Z7U0

    16. XM_047427056.1 → XP_047283012.1  serine/arginine repetitive matrix protein 1 isoform X8

      UniProtKB/TrEMBL
      B7Z7U0

    17. XM_047427126.1 → XP_047283082.1  serine/arginine repetitive matrix protein 1 isoform X11

      UniProtKB/TrEMBL
      B7Z7U0

    18. XM_047427145.1 → XP_047283101.1  serine/arginine repetitive matrix protein 1 isoform X12

      UniProtKB/TrEMBL
      B7Z7U0

    19. XM_017000034.2 → XP_016855523.1  serine/arginine repetitive matrix protein 1 isoform X21

      UniProtKB/TrEMBL
      B4DED5

    20. XM_047427315.1 → XP_047283271.1  serine/arginine repetitive matrix protein 1 isoform X18

      UniProtKB/TrEMBL
      B7Z7U0

    21. XM_047427340.1 → XP_047283296.1  serine/arginine repetitive matrix protein 1 isoform X19

      UniProtKB/TrEMBL
      B7Z7U0

    22. XM_047427357.1 → XP_047283313.1  serine/arginine repetitive matrix protein 1 isoform X20

      UniProtKB/TrEMBL
      B7Z7U0

    23. XM_047427270.1 → XP_047283226.1  serine/arginine repetitive matrix protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z7U0

    24. XM_047427257.1 → XP_047283213.1  serine/arginine repetitive matrix protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z7U0

    RNA

    1. XR_007062492.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      24481714..24511711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333782.1 → XP_054189757.1  serine/arginine repetitive matrix protein 1 isoform X14

      UniProtKB/TrEMBL
      B7Z7U0

    2. XM_054333783.1 → XP_054189758.1  serine/arginine repetitive matrix protein 1 isoform X15

      UniProtKB/TrEMBL
      B7Z7U0

    3. XM_054333781.1 → XP_054189756.1  serine/arginine repetitive matrix protein 1 isoform X13

      UniProtKB/TrEMBL
      B7Z7U0

    4. XM_054333784.1 → XP_054189759.1  serine/arginine repetitive matrix protein 1 isoform X16

      UniProtKB/TrEMBL
      B7Z7U0

    5. XM_054333791.1 → XP_054189766.1  serine/arginine repetitive matrix protein 1 isoform X22

    6. XM_054333792.1 → XP_054189767.1  serine/arginine repetitive matrix protein 1 isoform X23

    7. XM_054333771.1 → XP_054189746.1  serine/arginine repetitive matrix protein 1 isoform X3

      UniProtKB/TrEMBL
      B7Z7U0

    8. XM_054333769.1 → XP_054189744.1  serine/arginine repetitive matrix protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z7U0

    9. XM_054333772.1 → XP_054189747.1  serine/arginine repetitive matrix protein 1 isoform X4

      UniProtKB/TrEMBL
      B7Z7U0

    10. XM_054333773.1 → XP_054189748.1  serine/arginine repetitive matrix protein 1 isoform X5

      UniProtKB/TrEMBL
      B7Z7U0

    11. XM_054333770.1 → XP_054189745.1  serine/arginine repetitive matrix protein 1 isoform X2

      UniProtKB/TrEMBL
      B7Z7U0

    12. XM_054333774.1 → XP_054189749.1  serine/arginine repetitive matrix protein 1 isoform X6

      UniProtKB/TrEMBL
      B7Z7U0

    13. XM_054333777.1 → XP_054189752.1  serine/arginine repetitive matrix protein 1 isoform X9

      UniProtKB/TrEMBL
      B7Z7U0

    14. XM_054333775.1 → XP_054189750.1  serine/arginine repetitive matrix protein 1 isoform X7

      UniProtKB/TrEMBL
      B7Z7U0

    15. XM_054333778.1 → XP_054189753.1  serine/arginine repetitive matrix protein 1 isoform X10

      UniProtKB/TrEMBL
      B7Z7U0

    16. XM_054333776.1 → XP_054189751.1  serine/arginine repetitive matrix protein 1 isoform X8

      UniProtKB/TrEMBL
      B7Z7U0

    17. XM_054333779.1 → XP_054189754.1  serine/arginine repetitive matrix protein 1 isoform X11

      UniProtKB/TrEMBL
      B7Z7U0

    18. XM_054333780.1 → XP_054189755.1  serine/arginine repetitive matrix protein 1 isoform X12

      UniProtKB/TrEMBL
      B7Z7U0

    19. XM_054333790.1 → XP_054189765.1  serine/arginine repetitive matrix protein 1 isoform X21

      UniProtKB/TrEMBL
      B4DED5

    20. XM_054333787.1 → XP_054189762.1  serine/arginine repetitive matrix protein 1 isoform X18

      UniProtKB/TrEMBL
      B7Z7U0

    21. XM_054333788.1 → XP_054189763.1  serine/arginine repetitive matrix protein 1 isoform X19

      UniProtKB/TrEMBL
      B7Z7U0

    22. XM_054333789.1 → XP_054189764.1  serine/arginine repetitive matrix protein 1 isoform X20

      UniProtKB/TrEMBL
      B7Z7U0

    23. XM_054333786.1 → XP_054189761.1  serine/arginine repetitive matrix protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z7U0

    24. XM_054333785.1 → XP_054189760.1  serine/arginine repetitive matrix protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z7U0

    RNA

    1. XR_008485863.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYB3.2 GenPept UniProtKB/Swiss-Prot:Q8IYB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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