dpl-1 Transcription factor dpl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpl-1
Official Full Name: Transcription factor dpl-1
Primary source: WormBase:WBGene00001061
Locus tag: CELE_T23G7.1
See related: AllianceGenome:WB:WBGene00001061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gonad development; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including anal region; digestive tract; germ line; head; and midbody. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to human TFDP3 (transcription factor Dp family member 3); TFDP1 (transcription factor Dp-1); and TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (9169910..9172565)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DPL-1 transcriptional activity inhibits CDK-2 mRNA accumulation in C. elegans germline stem cells, which leads to slower S-phase entry and progression.
Title: GSK-3 promotes S-phase entry and progression in C. elegans germline stem cells to maintain tissue output.
DPL-1 acts with EFL-1 in developing oocytes to directly regulate a transcriptional program that couples the critical events of ovulation and fertilization.
Title: DPL-1 (DP) acts in the germ line to coordinate ovulation and fertilization in C. elegans.
DPL-1 and EFL-1, but not LIN-35, promote the expression of a negative regulator of MPK-1, the MAP kinase phosphatase LIP-1.
Title: The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.
identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death)
Title: DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.
Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components.
Title: Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23G7.1 (e-PCR)
- UniSTS:308096

T23G7.2 (e-PCR)
- UniSTS:308097

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor dpl-1

NP_495957.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9169910..9172565

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063556.8 → NP_495957.1 Transcription factor dpl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495957.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22703

Conserved Domains (4) summary

cd14458
Location:158 → 203

DP_DD; coiled coil [structural motif]

pfam02319
Location:71 → 152

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:159 → 296

DP; Transcription factor DP

pfam14179
Location:455 → 521

YppG; YppG-like protein