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    set-3 SET domain-containing protein 3 [ Caenorhabditis elegans ]

    Gene ID: 182356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-3
    Official Full Name
    SET domain-containing protein 3
    Primary source
    WormBase:WBGene00007403
    Locus tag
    CELE_C07A9.7
    See related
    AllianceGenome:WB:WBGene00007403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Is expressed in several structures, including AB; Psub1; germ line; hypodermis; and intestine. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (9691028..9694574, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Bestrophin homolog 5 Neighboring gene Protein BUD31 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
    2. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
    3. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SET domain-containing protein 3
    NP_499143.1
    • Confirmed by transcript evidence
    NP_871669.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9691028..9694574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181940.6 → NP_871669.1  SET domain-containing protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34318
      Conserved Domains (1) summary
      smart00317
      Location:220 → 271
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. NM_066742.6 → NP_499143.1  SET domain-containing protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34318, Q8I4M9
      Conserved Domains (1) summary
      smart00317
      Location:220 → 271
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34318.1

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