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    lipt-1 BPL/LPL catalytic domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lipt-1
    Official Full Name
    BPL/LPL catalytic domain-containing protein
    Primary source
    WormBase:WBGene00001590
    Locus tag
    CELE_C45G3.3
    See related
    AllianceGenome:WB:WBGene00001590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Predicted to be active in mitochondrion. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lipt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (9226905..9228184)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LIM domain protein;LIM zinc-binding domain-containing protein;Protein espinas Neighboring gene ncRNA Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene Gamma-tubulin interacting protein 2 Neighboring gene Gamma-secretase subunit aph-1 Neighboring gene Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defining Caenorhabditis elegans as a model system to investigate lipoic acid metabolism. Lavatelli A, et al. J Biol Chem, 2020 Oct 30. PMID 32843480, Free PMC Article
    2. Cell division. Oegema K, et al. WormBook, 2006 Jan 19. PMID 18050484, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein lipoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BPL/LPL catalytic domain-containing protein
    NP_001379231.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9226905..9228184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392789.1 → NP_001379231.1  BPL/LPL catalytic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45303, O45877
      Conserved Domains (1) summary
      cd16443
      Location:11 → 217
      LplA; lipoate-protein ligase
    Nucleotide Protein
    Heading Accession and Version

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