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    drd2b dopamine receptor D2b [ Danio rerio (zebrafish) ]

    Gene ID: 378719, updated on 27-Dec-2024

    Summary

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    Official Symbol
    drd2bprovided by ZNC
    Official Full Name
    dopamine receptor D2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030910-2
    See related
    Ensembl:ENSDARG00000011091 AllianceGenome:ZFIN:ZDB-GENE-030910-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    drd2c
    Summary
    Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled dopamine receptor signaling pathway; negative regulation of glutamatergic synaptic transmission; and regulation of dopamine secretion. Predicted to act upstream of or within G protein-coupled dopamine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and presynaptic membrane. Is expressed in nervous system and notochord. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See drd2b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (58072615..58173608, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (57404474..57503400, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490178 Neighboring gene B-cell translocation gene 4 Neighboring gene uncharacterized LOC137495641 Neighboring gene uncharacterized LOC137495642

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Boehmler W, et al. Dev Dyn, 2004 Jul. PMID 15188433
    2. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Liu NA, et al. Mol Endocrinol, 2006 Apr. PMID 16339273
    3. Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. Cleal M, et al. Neurobiol Aging, 2021 Jun. PMID 33676049
    4. Dopamine Receptors Gene Expression Pattern and Locomotor Improvement Differ Between Female and Male Zebrafish During Spinal Cord Auto Repair. Hosseini P, et al. Zebrafish, 2022 Aug. PMID 35905303
    5. Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease. Lv DJ, et al. Behav Brain Res, 2019 Oct 17. PMID 31195038

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that the a significantly higher expression of the dopamine D2 receptors (drd2a and drd2b) and the delta opioid receptor (DOR; oprd1b) in bold compared to shy fish.
      Title: Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha2-adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dopamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dopamine receptor D2b
    Names
    dopamine receptor D2c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197936.1 → NP_922918.1  dopamine receptor D2b

      See identical proteins and their annotated locations for NP_922918.1

      Status: PROVISIONAL

      Source sequence(s)
      AY333792
      UniProtKB/TrEMBL
      A0A8N7UZW8, Q7T1A1
      Related
      ENSDARP00000003786.5, ENSDART00000016418.6
      Conserved Domains (2) summary
      cd14964
      Location:35 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 446
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      58072615..58173608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476029.2 → XP_021331704.1  dopamine receptor D2b isoform X1

      UniProtKB/TrEMBL
      A0A8N7UZW8, Q7T1A1
      Related
      ENSDARP00000137874.1, ENSDART00000159087.2
      Conserved Domains (2) summary
      cd14964
      Location:35 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 446
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394617.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      402905..433480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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