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    dffb DNA fragmentation factor, beta polypeptide (caspase-activated DNase) [ Danio rerio (zebrafish) ]

    Gene ID: 373130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dffbprovided by ZNC
    Official Full Name
    DNA fragmentation factor, beta polypeptide (caspase-activated DNase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-4
    See related
    Ensembl:ENSDARG00000009748 AllianceGenome:ZFIN:ZDB-GENE-030826-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CAD
    Summary
    Predicted to enable DNA nuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dffb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (22277215..22282962)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (22255976..22261723)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene adherens junctions associated protein 1 Neighboring gene nephronophthisis 4 Neighboring gene si:ch211-147a11.3 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Zhou ZJ, et al. Front Cell Infect Microbiol, 2016. PMID 27471679, Free PMC Article
    2. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA fragmentation factor subunit beta
    Names
    DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194404.1 → NP_919385.1  DNA fragmentation factor subunit beta

      See identical proteins and their annotated locations for NP_919385.1

      Status: PROVISIONAL

      Source sequence(s)
      AF286179
      UniProtKB/TrEMBL
      Q568W7, Q9DGL7
      Related
      ENSDARP00000017240.4, ENSDART00000005989.6
      Conserved Domains (2) summary
      cd06535
      Location:6 → 82
      CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...
      pfam09230
      Location:102 → 326
      DFF40; DNA fragmentation factor 40 kDa

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      22277215..22282962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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