pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pde6aprovided by ZNC
Official Full Name: phosphodiesterase 6A, cGMP-specific, rod, alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-42
See related: Ensembl:ENSDARG00000000380 AllianceGenome:ZFIN:ZDB-GENE-030616-42
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:bz1d10.3; si:rp71-1d10.3
Summary: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and retina development in camera-type eye. Predicted to act upstream of or within signal transduction. Predicted to be active in photoreceptor outer segment membrane. Is expressed in retina; retinal neural layer; retinal photoreceptor layer; and retinal rod cell. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (25005401..25034169, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (24708156..24736924, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDE6alpha' activity is important for the survival of cones in zebrafish
Title: Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in photoreceptor outer segment membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Names: cGMP-specific

NP_001007161.1

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007160.2 → NP_001007161.1 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Status: VALIDATED

Source sequence(s)

AL645792

UniProtKB/TrEMBL

A0A8M1N2Q4, Q800E7

Related

ENSDARP00000000392.9, ENSDART00000000392.10

Conserved Domains (2) summary

smart00065
Location:255 → 442

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:559 → 803

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase