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    map1aa microtubule-associated protein 1Aa [ Danio rerio (zebrafish) ]

    Gene ID: 100151220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map1aaprovided by ZNC
    Official Full Name
    microtubule-associated protein 1Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100426-2
    See related
    Ensembl:ENSDARG00000059601 AllianceGenome:ZFIN:ZDB-GENE-100426-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7151905
    Summary
    Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Predicted to be part of microtubule associated complex. Predicted to be active in several cellular components, including dendrite; microtubule; and neuronal cell body. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See map1aa in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52830512..52876614, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52555254..52601585, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene mitochondrial methionyl-tRNA formyltransferase Neighboring gene diphosphoinositol pentakisphosphate kinase 1a Neighboring gene tumor protein p53 binding protein, 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene CDKN2A interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. Li L, et al. iScience, 2023 Apr 21. PMID 37009226, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein 1A; microtubule-associated protein 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      52830512..52876614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921037.8 → XP_001921072.3  microtubule-associated protein 1A isoform X1

      See identical proteins and their annotated locations for XP_001921072.3

      UniProtKB/TrEMBL
      A0A8M1QUZ1
      Conserved Domains (1) summary
      cl23716
      Location:232 → 283
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_005166530.5 → XP_005166587.1  microtubule-associated protein 1A isoform X1

      See identical proteins and their annotated locations for XP_005166587.1

      UniProtKB/TrEMBL
      A0A8M1QUZ1
      Related
      ENSDARP00000142517.2, ENSDART00000172910.3
      Conserved Domains (1) summary
      cl23716
      Location:232 → 283
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_068222731.1 → XP_068078832.1  microtubule-associated protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A8M1QUZ1

    4. XM_009303461.4 → XP_009301736.1  microtubule-associated protein 1A isoform X2

      UniProtKB/TrEMBL
      A0A140LH51, A0A8M3B1H0, F1QIM1
      Related
      ENSDARP00000142581.2, ENSDART00000172951.3
      Conserved Domains (1) summary
      cl23716
      Location:50 → 101
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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