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    eef2b eukaryotic translation elongation factor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 326929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef2bprovided by ZNC
    Official Full Name
    eukaryotic translation elongation factor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5128
    See related
    Ensembl:ENSDARG00000100371 AllianceGenome:ZFIN:ZDB-GENE-030131-5128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    EEF2; eef2l; fe49h02; zgc:63584; wu:fe49h02
    Summary
    Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Acts upstream of or within cellular response to xenobiotic stimulus and chordate embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including epidermis; immature eye; nervous system; tail bud; and trunk. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eef2b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57149033..57174950)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (56935811..56961728)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 42 Neighboring gene microRNA mir-7148 Neighboring gene armadillo repeat containing 6 Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene transfer RNA threonine (anticodon AGU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish. Zhang SH, et al. Int J Dev Biol, 2006. PMID 16525935
    2. Cloning and expression of translation elongation factor 2 (EF-2) in zebrafish. Zhang SH, et al. DNA Seq, 2008 Feb. PMID 18300156
    3. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. Hurem S, et al. PLoS One, 2017. PMID 28628668, Free PMC Article
    4. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
    5. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EF-2 is a developmentally regulated gene and might play important roles during the early development of zebrafish embryos.
      Title: Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63584

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 2b
    Names
    EF-2
    eukaryotic translation elongation factor 2, like
    NP_956752.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200458.2 → NP_956752.2  elongation factor 2b

      See identical proteins and their annotated locations for NP_956752.2

      Status: PROVISIONAL

      Source sequence(s)
      AY391422
      UniProtKB/Swiss-Prot
      A0A0R4IA71, Q6P3J5, Q6TNU5
      Related
      ENSDARP00000131100.1, ENSDART00000168497.2
      Conserved Domains (6) summary
      cd01885
      Location:20 → 233
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:574 → 746
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:742 → 821
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:1 → 858
      PTZ00416; elongation factor 2; Provisional
      cd03700
      Location:394 → 488
      EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
      cd16261
      Location:503 → 574
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      57149033..57174950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3J5.1 GenPept UniProtKB/Swiss-Prot:Q6P3J5

    Gene LinkOut

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