pth2ra parathyroid hormone 2 receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pth2raprovided by ZNC
Official Full Name: parathyroid hormone 2 receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991123-10
See related: Ensembl:ENSDARG00000006678 AllianceGenome:ZFIN:ZDB-GENE-991123-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pth2r; pthr2; zgc:123155
Summary: Enables parathyroid hormone receptor activity and peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastomere; bone tissue; central nervous system; optic vesicle; and pleuroperitoneal region. Orthologous to human PTH2R (parathyroid hormone 2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (29122039..29321641, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (29311293..29510919, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the expression of pth2 and pth2r mRNA in the ear at the same time suggesting a role in otic development.
Title: Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables parathyroid hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables parathyroid hormone receptor activity	IDA Inferred from Direct Assay more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: parathyroid hormone 2 receptor a

Names: PTH type-2 receptor variant SV19; hormone receptor; parathyroid hormone receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131377.1 → NP_571452.1 parathyroid hormone 2 receptor a

See identical proteins and their annotated locations for NP_571452.1

Status: PROVISIONAL

Source sequence(s)

AF132082

UniProtKB/TrEMBL

Q9PWB7

Related

ENSDARP00000009332.6, ENSDART00000014047.8

Conserved Domains (3) summary

cd14964
Location:172 → 196

7tm_GPCRs; TM helix 1 [structural motif]

pfam02793
Location:92 → 156

HRM; Hormone receptor domain

cl28897
Location:169 → 457

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

29122039..29321641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167661.5 → XP_005167718.1 parathyroid hormone 2 receptor a isoform X1

UniProtKB/TrEMBL

A0A8M2BFQ7

Conserved Domains (2) summary

pfam00002
Location:163 → 430

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:86 → 150

HRM; Hormone receptor domain