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    ikzf1 IKAROS family zinc finger 1 (Ikaros) [ Danio rerio (zebrafish) ]

    Gene ID: 30177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ikzf1provided by ZNC
    Official Full Name
    IKAROS family zinc finger 1 (Ikaros)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-304
    See related
    Ensembl:ENSDARG00000013539 AllianceGenome:ZFIN:ZDB-GENE-980526-304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ikaros; znfn1a1
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ikzf1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15957852..15994717, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15826860..15864090, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase Neighboring gene fidgetin-like 1 Neighboring gene uncharacterized LOC137487381 Neighboring gene uncharacterized LOC137487380 Neighboring gene sperm microtubule inner protein 7 Neighboring gene von Willebrand factor C domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Stage-specific and cell type-specific requirements of ikzf1 during haematopoietic differentiation in zebrafish. Hess I, et al. Sci Rep, 2022 Dec 10. PMID 36496511, Free PMC Article
    2. Thymus development in the zebrafish (Danio rerio) from an ecoimmunology perspective. Kernen L, et al. J Exp Zool A Ecol Integr Physiol, 2020 Dec. PMID 33306886
    3. Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study. Lam SH, et al. Dev Comp Immunol, 2004 Jan. PMID 12962979
    4. Evolutionary conservation of neuropeptide expression in the thymus of different species. Silva AB, et al. Immunology, 2006 May. PMID 16630030, Free PMC Article
    5. Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha. Mönnich M, et al. Eur J Immunol, 2010 Sep. PMID 20623552

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphoid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein Ikaros
    Names
    zinc finger protein, subfamily 1A, 1 (Ikaros)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130986.1 → NP_571061.1  DNA-binding protein Ikaros

      See identical proteins and their annotated locations for NP_571061.1

      Status: PROVISIONAL

      Source sequence(s)
      AF092175
      UniProtKB/TrEMBL
      A0A8M2B3C7, O93581
      Related
      ENSDARP00000013960.5, ENSDART00000016430.7
      Conserved Domains (4) summary
      COG5048
      Location:132 → 235
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:176 → 201
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15957852..15994717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156620.5 → XP_005156677.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8M2B2X4, A0A8M2B3I1
      Related
      ENSDARP00000050480.3, ENSDART00000050481.5
      Conserved Domains (4) summary
      COG5048
      Location:114 → 236
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:165 → 185
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:163 → 185
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:177 → 202
      zf-H2C2_2; Zinc-finger double domain

    2. XM_068224899.1 → XP_068081000.1  DNA-binding protein Ikaros isoform X4

      UniProtKB/TrEMBL
      A0A8M2B3I1

    3. XM_005156619.5 → XP_005156676.1  DNA-binding protein Ikaros isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2R4, A0A8M2B3C7
      Conserved Domains (3) summary
      COG5048
      Location:253 → 360
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:242 → 266
      zf-H2C2_2; Zinc-finger double domain

    4. XM_005156618.5 → XP_005156675.1  DNA-binding protein Ikaros isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2N6, A0A8M2B3C7
      Related
      ENSDARP00000074176.3, ENSDART00000079724.4
      Conserved Domains (3) summary
      COG5048
      Location:254 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:242 → 266
      zf-H2C2_2; Zinc-finger double domain

    5. XM_009307224.4 → XP_009305499.1  DNA-binding protein Ikaros isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3C7, A0A8M3AZ03
      Conserved Domains (4) summary
      COG5048
      Location:248 → 371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:266 → 288
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:280 → 305
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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