gata5 GATA binding protein 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gata5provided by ZNC
Official Full Name: GATA binding protein 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-340
See related: Ensembl:ENSDARG00000017821 AllianceGenome:ZFIN:ZDB-GENE-980526-340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gta5; cb634; fau/gata5
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of with a negative effect on gene expression. Acts upstream of or within several processes, including Kupffer's vesicle development; heart development; and post-embryonic foregut morphogenesis. Located in nucleus. Is expressed in several structures, including blastoderm; cardiovascular system; digestive system; mesoderm; and presumptive structure. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (7379800..7391000)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (7445828..7457028)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified GATA5 as a SUMO substrate, and lysine 324 (K324) and lysine 360 (K360) as two major modification sites
Title: GATA5 SUMOylation is indispensable for zebrafish cardiac development.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT signaling and expand the number of cardiac progenitors.
Title: Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.
Overexpression of smarcd3b and gata5 in zebrafish results in an enlarged heart, whereas combinatorial loss of cBAF components inhibits cardiac differentiation, demonstrating that Smarcd3b and Gata5 can induce a primitive, progenitor cell-like state.
Title: Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo.
First evidence for a regulatory function for gata5 in the formation of Kupffer's vesicle and left-right patterning.
Title: Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development.
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
Title: Redundancy and evolution of GATA factor requirements in development of the myocardium.
the gata5 genes are redundant for specification of cardiomyocytes.
Title: Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.
Grl forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.
Title: Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5.

Submit: New GeneRIF Correction

General gene information

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Markers

fc70f08.y1 (e-PCR)
- UniSTS:194319

gata5 (e-PCR), detects polymorphism
- UniSTS:205624

fe14b01.x1 (e-PCR)
- UniSTS:196180

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration to the midline involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within endoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_negative_effect gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myeloid dendritic cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor GATA-5

Names: fau; faust

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131235.2 → NP_571310.2 transcription factor GATA-5

See identical proteins and their annotated locations for NP_571310.2

Status: PROVISIONAL

Source sequence(s)

AJ242515

UniProtKB/TrEMBL

A0A8M1PAX0, Q9W6U0

Related

ENSDARP00000026381.8, ENSDART00000012194.9

Conserved Domains (3) summary

smart00401
Location:236 → 285

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:241 → 291

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:1 → 173

GATA-N; GATA-type transcription activator, N-terminal