dbx1b developing brain homeobox 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dbx1bprovided by ZNC
Official Full Name: developing brain homeobox 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000128-11
See related: Ensembl:ENSDARG00000001859 AllianceGenome:ZFIN:ZDB-GENE-000128-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hlx2; sb:eu236
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within cell differentiation in spinal cord. Predicted to be located in nucleus. Is expressed in several structures, including brain; hindbrain neural plate; neural tube; presumptive diencephalon; and spinal cord neural rod. Orthologous to human DBX1 (developing brain homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (14507567..14510477)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (14411167..14414077)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dbx1b marks the progenitor populations that give rise to the dorsal habenulae. In addition, the expression of dbx1b in the dorsal diencephalon is tightly controlled by FGF signaling.
Title: Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation in spinal cord	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation in spinal cord	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein DBX1-B

Names: H2.0-like homeobox 2; developing brain homeobox protein 1-B; homeobox protein hlx2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131178.1 → NP_571253.1 homeobox protein DBX1-B

See identical proteins and their annotated locations for NP_571253.1

Status: PROVISIONAL

Source sequence(s)

AF030285

UniProtKB/Swiss-Prot

Q9PTU0

UniProtKB/TrEMBL

B3DG51

Related

ENSDARP00000013350.4, ENSDART00000015681.6

Conserved Domains (2) summary

COG5576
Location:173 → 296

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:182 → 235

Homeobox; Homeobox domain