U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cd2ap CD2-associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 494040, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cd2approvided by ZNC
    Official Full Name
    CD2-associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8078
    See related
    Ensembl:ENSDARG00000015224 AllianceGenome:ZFIN:ZDB-GENE-030131-8078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cd2apl; fj51c01; im:7153970; wu:fj51c01; zgc:103705; si:ch211-207n9.1
    Summary
    Acts upstream of or within glomerular filtration and pronephric glomerulus development. Predicted to be active in several cellular components, including cell leading edge; plasma membrane; and vesicle. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cd2ap in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (35857386..35980219)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35954473..36077342)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F8 Neighboring gene tumor necrosis factor receptor superfamily, member 21 Neighboring gene golgin subfamily A member 6-like protein 25 Neighboring gene opsin 5 Neighboring gene patched domain containing 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Rapid screening of glomerular slit diaphragm integrity in larval zebrafish. Hentschel DM, et al. Am J Physiol Renal Physiol, 2007 Nov. PMID 17699558
    2. Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. Ito Y, et al. Am J Physiol Renal Physiol, 2017 Jun 1. PMID 28228401
    3. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Kuusela S, et al. Cell Death Dis, 2016 Jul 21. PMID 27441654, Free PMC Article
    4. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Schiffer M, et al. Nat Med, 2015 Jun. PMID 25962121, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.
      Title: Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephric glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell leading edge IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CD2-associated protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008583.2 → NP_001008583.2  CD2-associated protein

      Status: VALIDATED

      Source sequence(s)
      BC086846, BX511269, DT075242, DT081164, EB864755
      UniProtKB/TrEMBL
      A0A8M1N3I0, F1R1N9
      Related
      ENSDARP00000093386.3, ENSDART00000102611.5
      Conserved Domains (3) summary
      cd12053
      Location:12 → 58
      SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein
      cd12054
      Location:126 → 180
      SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
      cd12056
      Location:285 → 341
      SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      35857386..35980219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294709.4 → XP_009292984.1  CD2-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8M3AKU9
      Conserved Domains (3) summary
      cd12053
      Location:12 → 58
      SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein
      cd12054
      Location:126 → 180
      SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
      cd12056
      Location:285 → 341
      SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

    2. XM_005160684.5 → XP_005160741.1  CD2-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7J4
      Conserved Domains (2) summary
      cd12054
      Location:76 → 130
      SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
      cd12056
      Location:235 → 291
      SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools