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    eef1db eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) [ Danio rerio (zebrafish) ]

    Gene ID: 560745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef1dbprovided by ZNC
    Official Full Name
    eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6544
    See related
    Ensembl:ENSDARG00000030053 AllianceGenome:ZFIN:ZDB-GENE-030131-6544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eef1d; im:7233939; wu:fa14f09; zgc:114052; si:dkey-235d18.4
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eef1db in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (52546186..52582645)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (52740570..52777029)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene GDP-L-fucose synthase, tandem duplicate 2 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene si:ch211-221n20.8 Neighboring gene collagen alpha-1(I) chain Neighboring gene collagen alpha-1(I) chain-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114052

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
    Names
    elongation factor-1, delta, b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030147.2 → NP_001025318.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform 2

      See identical proteins and their annotated locations for NP_001025318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL929003, BC097116, EH506100
      UniProtKB/TrEMBL
      Q4V913, Q5SPD1
      Related
      ENSDARP00000100592.3, ENSDART00000110777.5
      Conserved Domains (1) summary
      pfam00736
      Location:191 → 274
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    2. NM_001161414.1 → NP_001154886.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform 1

      See identical proteins and their annotated locations for NP_001154886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL929003, BC097116, EB883411, EH506100
      UniProtKB/TrEMBL
      A4IGA1, Q5SPD0
      Related
      ENSDARP00000042703.5, ENSDART00000042704.7
      Conserved Domains (1) summary
      pfam00736
      Location:215 → 298
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      52546186..52582645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160918.5 → XP_005160975.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7W1
      Conserved Domains (1) summary
      pfam00736
      Location:495 → 578
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    2. XM_005160919.5 → XP_005160976.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7V6
      Conserved Domains (1) summary
      pfam00736
      Location:471 → 554
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    3. XM_005160920.5 → XP_005160977.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X3

      See identical proteins and their annotated locations for XP_005160977.1

      UniProtKB/TrEMBL
      A4IGA1, Q5SPD0
      Conserved Domains (1) summary
      pfam00736
      Location:215 → 298
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    4. XM_017352493.3 → XP_017207982.1  eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7W1
      Conserved Domains (1) summary
      pfam00736
      Location:495 → 578
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    Nucleotide Protein Strain
    Heading Accession and Version

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