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    hpxa hemopexin a [ Danio rerio (zebrafish) ]

    Gene ID: 327588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpxaprovided by ZNC
    Official Full Name
    hemopexin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5773
    See related
    Ensembl:ENSDARG00000012609 AllianceGenome:ZFIN:ZDB-GENE-030131-5773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hpx; hpx a; wu:fi17f11; wu:fi19a10
    Summary
    Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood; liver; and male organism. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hpxa in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (32840928..32847639, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (33030182..33036893, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene myxovirus (influenza virus) resistance C Neighboring gene myxovirus (influenza virus) resistance E Neighboring gene ankyrin repeat domain 50-like Neighboring gene uncharacterized LOC101883176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Reorganization of low-molecular-weight fraction of plasma proteins in the annual cycle of cyprinidae. Andreeva AM, et al. Biochemistry (Mosc), 2015 Feb. PMID 25756535
    2. Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. O'Shields B, et al. Biochim Biophys Acta, 2014 Sep. PMID 24751692, Free PMC Article
    3. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. Oka T, et al. BMC Physiol, 2010 Oct 21. PMID 20961460, Free PMC Article
    4. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Peterson SM, et al. Environ Health Perspect, 2011 May. PMID 21147602, Free PMC Article
    5. Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Feng J, et al. Food Funct, 2021 Nov 29. PMID 34783821

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hemopexin
    NP_001315463.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328534.1 → NP_001315463.1  hemopexin precursor

      Status: VALIDATED

      Source sequence(s)
      BC056563, CT030044
      UniProtKB/Swiss-Prot
      A9JSW7, Q6PHG2
      Related
      ENSDARP00000111337.2, ENSDART00000121506.4
      Conserved Domains (2) summary
      cd00094
      Location:49 → 243
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cl02471
      Location:257 → 445
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      32840928..32847639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001111147.1: Suppressed sequence

      Description
      NM_001111147.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHG2.2 GenPept UniProtKB/Swiss-Prot:Q6PHG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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