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    uqcrc2a ubiquinol-cytochrome c reductase core protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 436930, updated on 9-Dec-2024

    Summary

    Official Symbol
    uqcrc2aprovided by ZNC
    Official Full Name
    ubiquinol-cytochrome c reductase core protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-405
    See related
    Ensembl:ENSDARG00000014794 AllianceGenome:ZFIN:ZDB-GENE-040718-405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb33d01; fc43c05; zgc:92453; wu:fb33d01; wu:fc43c05
    Summary
    Predicted to enable metal ion binding activity. Predicted to be active in mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See uqcrc2a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (58167269..58185030)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (58096729..58133545)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:ch211-256e16.3 Neighboring gene stonustoxin subunit beta-like Neighboring gene NACHT, LRR and PYD domains-containing protein 3 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein a (U4/U6.U5) Neighboring gene protein NLRC3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquinol-cytochrome c reductase core protein 2a
    Names
    ubiquinol-cytochrome c reductase core protein IIa
    NP_001002657.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002657.2NP_001002657.2  ubiquinol-cytochrome c reductase core protein 2a

      Status: VALIDATED

      Source sequence(s)
      CT583687, EB969638, EH436572
      UniProtKB/TrEMBL
      A0A8M1N0Y0, F1QJE0
      Related
      ENSDARP00000015132.6, ENSDART00000010395.9
      Conserved Domains (3) summary
      COG0612
      Location:33443
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:55201
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:206385
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      58167269..58185030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)