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    gna13a guanine nucleotide binding protein (G protein), alpha 13a [ Danio rerio (zebrafish) ]

    Gene ID: 326825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gna13aprovided by ZNC
    Official Full Name
    guanine nucleotide binding protein (G protein), alpha 13aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5024
    See related
    Ensembl:ENSDARG00000073765 AllianceGenome:ZFIN:ZDB-GENE-030131-5024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gna13; wu:fe25e05; zgc:112436
    Summary
    Enables cadherin binding activity. Acts upstream of or within several processes, including endocardial progenitor cell migration to the midline involved in heart field formation; gastrulation; and glial cell development. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane and cytoplasm. Is expressed in brain; gill; head; and olfactory epithelium. Orthologous to human GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gna13a in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20552157..20565364)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805402.1 (37645..37935)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805585.1 (3550..4632)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496813 Neighboring gene uncharacterized LOC137496866 Neighboring gene archaemetzincin-2 Neighboring gene monocarboxylate transporter 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An ATX-LPA(6)-Gα(13)-ROCK axis shapes and maintains caudal vein plexus in zebrafish. Okasato R, et al. iScience, 2021 Nov 19. PMID 34755093, Free PMC Article
    2. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. Ackerman SD, et al. J Exp Med, 2018 Mar 5. PMID 29367382, Free PMC Article
    3. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. Lin F, et al. J Cell Biol, 2009 Mar 23. PMID 19307601, Free PMC Article
    4. Gα13 is closely related to hematopoiesis in zebrafish. Ye D, et al. Mol Biol Rep, 2011 Apr. PMID 21113681
    5. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Chen L, et al. Environ Sci Technol, 2017 Feb 7. PMID 28026967

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA
      Title: The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
    2. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
      Title: Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration involved in heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endocardial progenitor cell migration to the midline involved in heart field formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination of posterior lateral line nerve axons IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell-cell adhesion mediated by cadherin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit alpha-13a
    Names
    Galpha 13a
    guanine nucleotide-binding protein subunit alpha-13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012243.3 → NP_001012243.3  guanine nucleotide-binding protein subunit alpha-13a

      Status: VALIDATED

      Source sequence(s)
      EH546568, EH567709, FP885542
      UniProtKB/TrEMBL
      A0A8M9Q880, F1QXP2, Q4VBH5, Q5YKG3
      Related
      ENSDARP00000102226.3, ENSDART00000113224.4
      Conserved Domains (1) summary
      smart00275
      Location:27 → 374
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      20552157..20565364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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